Polyoma Virus, Medium T Antigen Antibody (PyMT) [DyLight 405]

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Product Details

Summary
Reactivity ViSpecies Glossary
Applications WB, ICC/IF
Clone
PyMT
Clonality
Monoclonal
Host
Rat
Conjugate
DyLight 405

Polyoma Virus, Medium T Antigen Antibody (PyMT) [DyLight 405] Summary

Immunogen
Polyoma Virus-transformed Wistar rat fibroblast cell line Py REWA5/T1A1.
Localization
Cytoplasmic location in cells infected with virus.
Isotype
IgG2b
Clonality
Monoclonal
Host
Rat
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • Immunocytochemistry/Immunofluorescence
Application Notes
This Polyoma Virus, Medium T Antigen antibody is useful for Immunocytochemistry/Immunofluorescence, Immunoprecipitation and Western Blot. NB100-2749 is useful for the detection and isolation of the Middle T Antigen.

Reactivity Notes

Polyoma Virus

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Polyoma Virus, Medium T Antigen Antibody (PyMT) [DyLight 405]

  • Middle t antigen
  • MPyVgp2
  • Polyoma virus middle T antigen
  • Polyomavirus medium t antigen
  • Polyomavirus middle t antigen

Background

Polyoma Viruses are a class of potentially oncogenic DNA viruses that often persist as latent infections in a host without causing disease, but may produce tumors in a host of a different species. Of particular interest, is that only the rodent Polyoma Viruses code for the production of PyMT (Medium T Antigen). This oncogenic protein of the Polyoma Virus is associated with cell membranes and interacts with a variety of cellular proteins involved in mitogenic signaling, such as tyrosine kinases c-Src, c-Yes, and Fyn. Medium T Antigen may therefore mimic the function of cellular tyrosine kinase growth factor receptors, like the platelet-derived growth factor or epidermal growth factor receptor (PMCID: PMC191984). Furthermore, it has been found that the Medium T Antigen may have a mechanism for inactivating p53, as it seems to be a characteristic of oncogenic DNA viruses (PMID: 22261839).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

DyLight 350 Labeled NB100-2749UV
DyLight 488 Labeled NB100-2749G
DyLight 680 Labeled NB100-2749FR
DyLight 755 Labeled NB100-2749IR
FITC Labeled NB100-2749F

Additional Polyoma Virus, Medium T Antigen Products

Polyoma Virus, Medium T Antigen NB100-2749V

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