Oval Cell Marker Antibody (MIC1-1C3) [PE]

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications Flow
Clone
MIC1-1C3
Clonality
Monoclonal
Host
Rat
Conjugate
PE

Oval Cell Marker Antibody (MIC1-1C3) [PE] Summary

Immunogen
Nonparenchymal cells from DDC-treated mice
Localization
Cell surface
Marker
Hepatic periductal cell Marker
Specificity
Specific for hepatic proliferating duct cells.
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry
Application Notes
This Oval Cell Marker (MIC1-1C3) antibody is useful for Immunohistochemistry on acetone fixed frozen sections and Flow cytometry. Immunocytochemistry/Immunofluorescence and Immunohistochemistry-Paraffin were reported in scientific literature.

Reactivity Notes

Mouse.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Oval Cell Marker Antibody (MIC1-1C3) [PE]

  • macrophage inhibitory cytokine-1

Background

Liver is well known to possess facultative stem cells which can be activated in response to injury and hepatic stem cell activation was first described in rat model, wherein, chemical damage in combination with partial hepatectomy resulted in the emergence of a new cell type which was described according to its nuclear morphology as "oval cells". The word 'oval cells' is now employed to define population of small proliferating cells with oval-shaped nuclei which arise within liver tissue following certain types of hepatic injury. Oval cell proliferation is activated when the proliferative capacity of hepatocytes is impaired, as well as in certain models of carcinogenesis. Histologically, hepatic tissue is highly complex and contains many different cell types including various kinds of hepatocytes, ducts, hematopoietic cells, endothelial cells, macrophages, stellate cells etc., and the oval cells have been proposed to be bipotential progenitor cells capable of generating both hepatocytes and bile ducts. Due to their bipotency and high clonogenicity, oval cells have been considered putative liver stem cells and research is in progress for elucidation of signaling molecules involved in controlling the activation, proliferation and differentiation of this unique cell population. Our oval cell antibodies have been developed against hepatic nonparenchymal cells (NPCs) from mice undergoing oval cell activation and with these antibodies, it is now possible to perform microarray analysis of distinct liver cell populations during induced oval cell response or certain pathological conditions.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Allophycocyanin Labeled NBP1-18961APC
Biotin Labeled NBP1-18961B
DyLight 350 Labeled NBP1-18961UV
DyLight 405 Labeled NBP1-18961V
DyLight 488 Labeled NBP1-18961G
DyLight 550 Labeled NBP1-18961R
DyLight 650 Labeled NBP1-18961C
DyLight 680 Labeled NBP1-18961FR
DyLight 755 Labeled NBP1-18961IR
FITC Labeled NBP1-18961F
HRP Labeled NBP1-18961H
PerCP Labeled NBP1-18961PCP

Additional Oval Cell Marker Products

Oval Cell Marker NBP1-18961PE

Research Areas for Oval Cell Marker Antibody (NBP1-18961PE)

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