Oval Cell Marker Antibody (MIC1-1C3) [PE]

Images

 
Flow Cytometry: Oval Cell Marker Antibody (MIC1-1C3) [PE] [NBP1-18961PE] - Flow cytometry of wildtype mouse liver showing unstained vs. MIC1-1C3 single stained controls. Flow cytometry image submitted by a verified ...read more

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications Flow, ICC/IF, IHC, CyTOF-ready
Clone
MIC1-1C3
Clonality
Monoclonal
Host
Rat
Conjugate
PE

Order Details

Oval Cell Marker Antibody (MIC1-1C3) [PE] Summary

Immunogen
Nonparenchymal cells from DDC-treated mice
Localization
Cell surface
Marker
Hepatic periductal cell Marker
Specificity
Specific for hepatic proliferating duct cells.
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Reviewed Applications
Read 1 Review rated 5
using
NBP1-18961PE in the following applications:

Reactivity Notes

Human reactivity reported in scientific literature (PMID: 30236451).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Background

Liver is well known to possess facultative stem cells which can be activated in response to injury and hepatic stem cell activation was first described in rat model, wherein, chemical damage in combination with partial hepatectomy resulted in the emergence of a new cell type which was described according to its nuclear morphology as "oval cells". The word 'oval cells' is now employed to define population of small proliferating cells with oval-shaped nuclei which arise within liver tissue following certain types of hepatic injury. Oval cell proliferation is activated when the proliferative capacity of hepatocytes is impaired, as well as in certain models of carcinogenesis. Histologically, hepatic tissue is highly complex and contains many different cell types including various kinds of hepatocytes, ducts, hematopoietic cells, endothelial cells, macrophages, stellate cells etc., and the oval cells have been proposed to be bipotential progenitor cells capable of generating both hepatocytes and bile ducts. Due to their bipotency and high clonogenicity, oval cells have been considered putative liver stem cells and research is in progress for elucidation of signaling molecules involved in controlling the activation, proliferation and differentiation of this unique cell population. Our oval cell antibodies have been developed against hepatic nonparenchymal cells (NPCs) from mice undergoing oval cell activation and with these antibodies, it is now possible to perform microarray analysis of distinct liver cell populations during induced oval cell response or certain pathological conditions.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Oval Cell Marker Antibody (NBP1-18961PE) (0)

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Review for Oval Cell Marker Antibody (NBP1-18961PE) (1) 51

Average Rating: 5
(Based on 1 review)
We have 1 review tested in 1 species: Mouse.

Reviews using NBP1-18961PE:
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Images Ratings Applications Species Date Details
Flow Cytometry Oval Cell Marker NBP1-18961PE
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5
reviewed by:
Verified Customer
Flow Mouse 06/04/2021
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Summary

ApplicationFlow Cytometry
Sample TestedLiver
SpeciesMouse
Lot082718-2-033021-PE

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

ICC/IF Video Protocol

FAQs for Oval Cell Marker Antibody (NBP1-18961PE) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Additional Oval Cell Marker Products

Array NBP1-18961PE

Research Areas for Oval Cell Marker Antibody (NBP1-18961PE)

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Blogs on Oval Cell Marker

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Calculators

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Verified Customer
06/04/2021
Application: Flow
Species: Mouse