Oval Cell Marker Antibody (MIC1-1C3)


Immunohistochemistry: Oval Cell Marker Antibody (MIC1-1C3) [NBP1-18961] - Immunohistochemical analysis of DDC treated mouse liver.

Product Details

Reactivity MuSpecies Glossary
Applications Flow, ICC/IF, IHC, IHC-Fr, IHC-P
1.0 mg/ml

Oval Cell Marker Antibody (MIC1-1C3) Summary

Nonparenchymal cells from DDC-treated mice
Cell surface
Hepatic periductal cell Marker
Specific for hepatic proliferating duct cells.
Protein G purified
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Packaging, Storage & Formulations

Store at 4C. Do not freeze.
0.09% Sodium Azide
1.0 mg/ml
Protein G purified


  • Flow Cytometry 1:50-1:100
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry 1:100
  • Immunohistochemistry-Frozen 1:100
  • Immunohistochemistry-Paraffin
Application Notes
This Oval Cell Marker (MIC1-1C3) antibody is useful for Immunohistochemistry on acetone fixed frozen sections and Flow cytometry. Immunocytochemistry/Immunofluorescence and Immunohistochemistry-Paraffin were reported in scientific literature.
Read Publications using
NBP1-18961 in the following applications:

Reactivity Notes


Alternate Names for Oval Cell Marker Antibody (MIC1-1C3)

  • macrophage inhibitory cytokine-1


Liver is well known to possess facultative stem cells which can be activated in response to injury and hepatic stem cell activation was first described in rat model, wherein, chemical damage in combination with partial hepatectomy resulted in the emergence of a new cell type which was described according to its nuclear morphology as "oval cells". The word 'oval cells' is now employed to define population of small proliferating cells with oval-shaped nuclei which arise within liver tissue following certain types of hepatic injury. Oval cell proliferation is activated when the proliferative capacity of hepatocytes is impaired, as well as in certain models of carcinogenesis. Histologically, hepatic tissue is highly complex and contains many different cell types including various kinds of hepatocytes, ducts, hematopoietic cells, endothelial cells, macrophages, stellate cells etc., and the oval cells have been proposed to be bipotential progenitor cells capable of generating both hepatocytes and bile ducts. Due to their bipotency and high clonogenicity, oval cells have been considered putative liver stem cells and research is in progress for elucidation of signaling molecules involved in controlling the activation, proliferation and differentiation of this unique cell population. Our oval cell antibodies have been developed against hepatic nonparenchymal cells (NPCs) from mice undergoing oval cell activation and with these antibodies, it is now possible to perform microarray analysis of distinct liver cell populations during induced oval cell response or certain pathological conditions.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Oval Cell Marker Antibody (NBP1-18961)(6)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 4 applications: FLOW, ICC/IF, IHC-Fr, IHC-P.

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Showing Publications 1 - 6 of 6.
Publications using NBP1-18961 Applications Species
Lu XF, Zhou YJ, Zhang L et al. Loss of Dicer1 impairs hepatocyte survival and leads to chronic inflammation and progenitor cell activation World J. Gastroenterol. 2015 Jun 07 [PMID:26074697] (IHC-P, Mouse) IHC-P Mouse
Bird TG, Lu WY, Boulter L et al. Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling Proc Natl Acad Sci U S A 2013 Apr 1 [PMID:23576749] (IHC-P, ICC/IF, Mouse) IHC-P, ICC/IF Mouse
Dorrell C, Erker L, Schug J, Kopp JL, Canaday PS, Fox AJ, Smirnova O, Duncan AW, Finegold MJ, Sander M, Kaestner KH, Grompe M. Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice. Genes Dev;25(11):1193-203. 2011 Jun 1. [PMID:21632826] (FLOW, Mouse) FLOW Mouse
Dorrell C, Grompe MT, Pan FC, Zhong Y, Canaday PS, Shultz LD, Greiner DL, Wright CV, Streeter PR, Grompe M. Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers. Mol Cell Endocrinol;339(1-2):144-50. 2011 Jun 6. [PMID:21539888] (FLOW, Mouse) FLOW Mouse
Lu L, Li Y, Kim SM, Bossuyt W, Liu P, Qiu Q, Wang Y, Halder G, Finegold MJ, Lee JS, Johnson RL. Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci U S A;107(4):1437-42. 2010 Jan 26. [PMID:20080689] (IHC-Fr, Mouse) IHC-Fr Mouse
Dorrell, C et al. Surface markers for the murine oval cell response. Hepatology;48(4):1282-91. 2008 Oct. [PMID:18726953] (IHC-Fr, FLOW, Mouse) IHC-Fr, FLOW Mouse

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

ICC/IF Video Protocol

FAQs for Oval Cell Marker Antibody (NBP1-18961). (Showing 1 - 1 of 1 FAQs).

  1. What is the recommended antigen retrieval conditions for IHC(P)?
    • The validation for IHC in paraffin embedded sections came from the following publication: NCBI site. In this publication, the authors used 3mm thick paraffin embedded tissue sections smeared on a slide fixed with methanol at 4 degrees C for 5 minutes. Therefore, we do not have a recommended antigen retrieval method. If you are trying to stain in formalin or paraformaldehyde fixed sections, I would recommend starting with either citrate buffer pH 6.0 or proteinase K for antigen retrieval.

Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor (R) 405 Labeled NBP1-18961AF405
Alexa Fluor (R) 488 Labeled NBP1-18961AF488
Alexa Fluor (R) 647 Labeled NBP1-18961AF647
Alexa Fluor (R) 700 Labeled NBP1-18961AF700
Allophycocyanin Labeled NBP1-18961APC
Biotin Labeled NBP1-18961B
DyLight 350 Labeled NBP1-18961UV
DyLight 405 Labeled NBP1-18961V
DyLight 405LS Labeled NBP1-18961V3
DyLight 488 Labeled NBP1-18961G
DyLight 550 Labeled NBP1-18961R
DyLight 650 Labeled NBP1-18961C
DyLight 680 Labeled NBP1-18961FR
DyLight 755 Labeled NBP1-18961IR
FITC Labeled NBP1-18961F
HRP Labeled NBP1-18961H
PE Labeled NBP1-18961PE
PerCP Labeled NBP1-18961PCP

Additional Oval Cell Marker Antibody (MIC1-1C3) Products

Oval Cell Marker NBP1-18961

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