Methionine Aminopeptidase 1D/MAP1D Antibody [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor Plus 647

Methionine Aminopeptidase 1D/MAP1D Antibody [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects human Methionine Aminopeptidase 1D/MAP1D in direct ELISAs and Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Methionine Aminopeptidase 1D/MAP1D Antibody [Alexa Fluor™ Plus 647]

• EC 3.4.11.18
• MAP1D
• MAP1DCDS of metAP-3 within PCR fragment
• MetAP1D
• Metap1l
• Methionine Aminopeptidase 1D
• methionine aminopeptidase 1D, mitochondrial
• methionyl aminopeptidase type 1D (mitochondrial)
• Methionyl aminopeptidase type 1D, mitochondrial

Background

Methionine Aminopeptidase 1D (MAP1D) is a member of the Methionine Aminopeptidase family (MetAPs) (1). MetAPs catalyze the removal of the initiator methionine residue from nascent peptides (2) and are essential for cell growth (3). MAP1D is localized in mitochondria (4) and is over-expressed in colon cancer cell lines and colon tumors (1). The N-terminal leader peptide (residue 1‑43) of MAP1D has been shown to be responsible for targeting to mitochondria (4).

1. Leszczyniecka, M. et al. (2006) Oncogene 25:3471.
2. Lowther, W.T. and B.W. Matthews (2000) Biochim. Biophys. Acta. 1477:157.
3. Li, X. and Y.H. Chang (1995) Proc. Natl. Acad. Sci. USA 92:12357.
4. Serero, A. et al. (2003) J. Biol. Chem. 278:52953.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.