LANA2 Antibody (CM-A807) [FITC]

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Product Details

Summary
Reactivity Hu, Mu, ViSpecies Glossary
Applications ELISA, ICC/IF, IHC-Fr, IHC-P
Clone
CM-A807
Clonality
Monoclonal
Host
Mouse
Conjugate
FITC

LANA2 Antibody (CM-A807) [FITC] Summary

Immunogen
Recombinant LANA2 fusion protein.
Localization
Nuclear
Specificity
This is specific for KSHV LANA2 (residues 143-310 epitope recognition).
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
Application Notes
This LANA2 (CM-A807) antibody is useful for ELISA, Immunocytochemistry/Immunofluorescence, Immunohistochemistry on frozen and paraffin-embedded sections, Immunoprecipitation and Western Blot. By Western Blot, this antibody recognizes a viral protein in KSHV infected B-cells (~66-70 kDa).

Reactivity Notes

Reacts with viral LANA2 protein and shows no cross-reactivity to cellular proteins. Also reacts with human and mouse viral KSHV proteins.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for LANA2 Antibody (CM-A807) [FITC]

  • LANA 2
  • LANA-2
  • Latency-associated nuclear antigen 2
  • vIRF 3
  • vIRF3
  • vIRF-3

Background

LANA2 (latency-associated nuclear antigen 2; also known as viral interferon regulatory factor 3) is a Kaposi's sarcoma-associated herpesvirus (KSHV) latent protein which is encoded by ORFK10.5 and is exclusively expressed by virus infected B- cells. LANA2 has been shown to be critical in KSHV-mediated tumorigenesis as it inhibits p53 function, dsRNA-activated protein kinase R (PKR)-dependent apoptosis, nuclear factor kB activity, interferon regulatory factor 7-mediated interferon signal transduction and virus-mediated transcriptional activation of the alpha-interferon promoter. LANA2 stabilizes and triggers the induction of HIF-1alpha's transcriptional activity and disrupts PODs (PML oncogenic domains). Moreover, LANA2 has been shown to be required for the survival of primary effusion lymphoma (PEL) cells infected with KSHV alone or dually infected by Epstein-Barr virus (EBV) and KSHV, wherein it shows nuclear and cytoplasmic expression.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

FAQs for LANA2 Antibody (NB200-167F) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Biotin Labeled NB200-167B
DyLight 350 Labeled NB200-167UV
DyLight 405 Labeled NB200-167V
DyLight 488 Labeled NB200-167G
DyLight 550 Labeled NB200-167R
DyLight 650 Labeled NB200-167C
DyLight 680 Labeled NB200-167FR
DyLight 755 Labeled NB200-167IR
HRP Labeled NB200-167H

Additional LANA2 Products

LANA2 NB200-167F

Research Areas for LANA2 Antibody (NB200-167F)

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