KDELR3 Antibody (KD10-2)

Product Discontinued

KDELR3 Antibody (KD10-2) Summary

• Immunogen: C-terminal for KDELR3 protein was used as the immunogen for this antibody.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Mouse
• Gene: KDELR3
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunofluorescence
  • Western Blot

Packaging, Storage & Formulations

• Storage: Lyophilized antibody can be kept at 4C for up to 3 months and should be kept at -20C for long-term storage. To avoid freeze-thaw cycles, reconstituted antibody should be aliquoted before freezing for short-term storage (-20C) or for long-term storage (-80C). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
• Buffer: PBS
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Protein G purified
• Reconstitution Instructions: Reconstitute with 0.1 ml water.

Alternate Names for KDELR3 Antibody (KD10-2)

• ER lumen protein retaining receptor 3
• ERD2L3
• KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
• KDEL endoplasmic reticulum protein retention receptor 3
• KDEL receptor 3

Background

Soluble proteins in the endoplasmic reticulum (ER) contain a specific carboxy terminal sequence KDEL (Lys-Asp-Glu-Leu), and include the coat proteins required for vesicle budding from the ER, proteins that form retrogradevesicles on post-ER compartments, and integral membrane proteins that target vesicles to their correct destination. The retention of these soluble proteins in the ER depends on the interaction of the KDEL sequence with the corresponding KDEL receptor, also designated ERD2, in the Golgi apparatus.When KDEL proteins reach the Golgi complex, they are recognized by the KDEL receptor and transported retrograde in COPI-coated vesicles back to the ER. The small GTPase ADP-ribosylation factor 1 (ARF1), a regulator of vesicle transport, interacts with the KDEL receptor.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: KDELR3
• Uniprot:
  • P24390(Human)