FOLR4 Antibody

Images

 
Western blot shows lysates of mouse CD+CD25+ regulatory T cells. PVDF Membrane was probed with 1 µg/mL of Sheep Anti-Mouse FOLR4 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6124) followed by ...read more
Mouse splenocytes gated on FoxP3 cells treated with 10 μL/mL anti-CD3/anti-CD28, Recombinant Mouse IL-2 (Catalog # 402-ML), and Human TGF-beta 1 (Catalog # 100-B) for 3 days to induce T regulatory cells (Tregs) were ...read more

Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB, Flow, CyTOF-ready
Clonality
Polyclonal
Host
Sheep
Conjugate
Unconjugated
Concentration
LYOPH

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Catalog# & Formulation Size Price

FOLR4 Antibody Summary

Immunogen
E. coli-derived recombinant mouse FOLR4
Gly20-Ser100
Accession # Q9EQF4
Specificity
Detects mouse FOLR4 in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) FOLR1, rhFOLR2, rhFOLR3, and rhFOLR4 is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Sheep
Gene
FOLR4
Purity
Immunogen affinity purified
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
  • Flow Cytometry 2.5 ug/10^6 cells
  • CyTOF-ready

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Immunogen affinity purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for FOLR4 Antibody

  • folate receptor 4 (delta) homolog (mouse)
  • Folbp3
  • FOLR4
  • FR-delta
  • LOC390243
  • probable folate receptor delta

Background

FOLR4 (folate receptor 4; also FR4, FR‑δ and FOLBP‑3) is a 35 kDa glycoprotein member of the folate receptor family. It is found on mouse Treg cells, particularly those classified as natural and CD4+ CD25- T cells that produce low amounts of IFN-gamma. Its function is unclear. Although folate family receptors can internalize folate, they are generally not the principal conduits for folate uptake. Mouse FOLR4 preproprecursor is 244 amino acids (aa) in length. It contains a 19 aa signal sequence plus a 225 aa proform. While there are no definitive structural motifs, there is presumably a C-terminal propeptide that gives rise to a GPI-linkage. There are three potential isoforms. One is 37 kDa in size and shows a 36 aa insertion after Glu155. Two others show a deletion of aa 47‑109, and a 17 aa substitution for aa 157‑244. Over aa 20‑100, mouse FOLR4 shares 84% and 70% aa identity with rat and human FOLR4, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol FOLR4
Uniprot