ATG11 Antibody (7C2NB) - BSA Free

Western Blot: ATG11 Antibody (7C2NB) [NBP2-47124] - Western blot analysis of ATG11 antibody in partial recombinant ATG11 protein.

• Reactivity: Ye
• Applications: WB
• Clone: 7C2NB
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1.0 mg/ml

ATG11 Antibody (7C2NB) - BSA Free Summary

• Description: Novus Biologicals Mouse ATG11 Antibody (7C2NB) - BSA Free (NBP2-47124) is a monoclonal antibody validated for use in WB. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Partial recombinant protein made to an internal sequence of the S. cerevisiae ATG11 protein (between amino acids 50-250) [UniProt Q12527]
• Isotype: IgM Lambda
• Clonality: Monoclonal
• Host: Mouse
• Gene: ATG11
• Purity: IgM purified

Applications/Dilutions

• Dilutions:
  • Western Blot 0.5 ug/ml

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: IgM purified

Alternate Names for ATG11 Antibody (7C2NB) - BSA Free

• CVT3
• CVT9

Background

ATG11 (autophagy-related protein 11), also called cytoplasm to vacuole targeting protein 9/CVT9, is expressed in Saccharomyces cerevisiae (Baker's Yeast). As a scaffold protein and a selective autophagy adaptor, it interacts with several different cargo receptors to mediate various kind of selective autophagy. Atg11 recognizes and transports substrates to the pre-autophagosomal structure/PAS, the site of autophagosome formation. ATG11 was identified by Lipatova et al and they found it to be an effector of the Rab Ypt1 and the TRAPPIII complex during selective macroautophagy. ATG11 is now known to bind with Atg19, Atg32, Atg36 etc. and it involves in cytoplasm to vacuole transport/CVT pathway, pexophagy, mitophagy and nucleophagy. Atg11 interacts with Atg1 and Atg17 also, which connects the cargo selection step to autophagosome formation. ATG11 gets recruited to the degrading mitochondria by ATG32, and Atg11 in turn brings Dnm1 as well as other proteins implicated in mitochondrial fission to the affected mitochondria for promoting their division. ATG11 is essential for ATG9 anterograde transport from the mitochondria to the PAS and it recruits ATG19-prAPE1 complex also to the PAS.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ATG11