Species: Ye
Applications: WB
Host: Mouse Monoclonal
Description
ATG11 (autophagy-related protein 11), also called cytoplasm to vacuole targeting protein 9/CVT9, is expressed in Saccharomyces cerevisiae (Baker's Yeast). As a scaffold protein and a selective autophagy adaptor, it interacts with several different cargo receptors to mediate various kind of selective autophagy. Atg11 recognizes and transports substrates to the pre-autophagosomal structure/PAS, the site of autophagosome formation. ATG11 was identified by Lipatova et al and they found it to be an effector of the Rab Ypt1 and the TRAPPIII complex during selective macroautophagy. ATG11 is now known to bind with Atg19, Atg32, Atg36 etc. and it involves in cytoplasm to vacuole transport/CVT pathway, pexophagy, mitophagy and nucleophagy. Atg11 interacts with Atg1 and Atg17 also, which connects the cargo selection step to autophagosome formation. ATG11 gets recruited to the degrading mitochondria by ATG32, and Atg11 in turn brings Dnm1 as well as other proteins implicated in mitochondrial fission to the affected mitochondria for promoting their division. ATG11 is essential for ATG9 anterograde transport from the mitochondria to the PAS and it recruits ATG19-prAPE1 complex also to the PAS.
Bioinformatics
| Product By Gene ID |
856162 |
| Alternate Names |
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Research Areas for ATG11
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Autophagy
