Periostin/OSF-2 Products

Description

Periostin is a disulfide linked 90 kDa 811 amno acid protein originally isolated as a osteoblastspecific factor that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading. Additionally, periostin expression has previously been shown to be significantly increased by both transforming growth factor beta-1(TGFbeta1) and bone morphogenetic protein (BMP)-2. OSF-2 has a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain and a C-terminal domain. The fourfold repeated domain of OSF-2 shows homology with the insect protein fasciclin. Periostin mRNA is expressed in the developing mouse embryonic and fetal heart, and that it is localized to the endocardial cushions that ultimately divide the primitive heart tube into a four-chambered heart.

Bioinformatics

Uniprot	NP_001129407 Human Q15063 Human Q62009 Mouse
Product By Gene ID	10631
Alternate Names	MGC119510 MGC119511 OSF-2osteoblast specific factor 2 (fasciclin I-like) OSF2periodontal ligament-specific periostin Osteoblast-specific factor 2 PDLPOSTN periostin isoform thy2 periostin isoform thy4 periostin isoform thy6 periostin isoform thy8 periostin periostin, osteoblast specific factor PNRP11-412K4.1