OATP1B3/SLCO1B3/OATP8 Products

Description

Several multispecific OATs (OAT1-3, OAT-K1 and OATK2) and OATPs (organic anion transporting polypeptides; oatp1-3, LST-1, and PGT), have been cloned and characterized from various tissues. The OATP family of proteins share significant sequence homology, and general secondary protein structure (up to 12 transmembrane domains with cytoplasmic N and C-terminus). Oatp2 (also called OATP-B1; 661 aa; 12 TM), cloned from rat brain, shares significant homology with rat oatp1 and OAT-K1 (77%) and human OATP (73%). It is highly expressed in brain, liver, and kidney but not in heart, spleen, lung, muscle, and testes. OATP2 mediates uptake of taurocholate, estrogen conjugates, and cardiac glycosides ouabain. Unlike other OATPS, OATP2 also transport digioxin.

Bioinformatics

Entrez	28234 Human
Uniprot	Q9NPD5 Human
Product By Gene ID	28234
Alternate Names	Liver-specific organic anion transporter 2 liver-specific organic anion transporter 3TM13 LST2 LST-2 LST3 OATP1B3 OATP1B3LST-3TM13 OATP8 OATP-8 Organic anion transporter 8 organic anion transporter LST-3c Organic anion-transporting polypeptide 8 SLC21A8 SLCO1B3 solute carrier family 21 (organic anion transporter), member 8 Solute carrier family 21 member 8 solute carrier organic anion transporter family member 1B3 solute carrier organic anion transporter family, member 1B3

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Cancer

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OATP8 - A membrane transport protein responsible for cancer drug uptake Human hepatocytes express important transport proteins that are responsible for the uptake and removal of organic anions from the blood. These proteins are members of the organic anion-transporting polypeptide (OATP) family and are essential for pr...    Read more.

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