NALP12 Products

Description

Position of the Chimera RNAi. The related RNAi products listed were designed from different accesion number but sharing the same RNAi sequence. Chimera RNA interference (chimera RNAi) is process by which small interfering RNA/DNA chimera triggers the destruction of mRNA for the original gene.  The discovery work, design, and application of chimera RNAi has been pioneered by Professor Kaoru Saigo and Dr. Kumiko Ui-Tei at the University of Tokyo.  Chimera RNAi has many advantages over the conventional siRNAs.  First, it has been demonstrated to have reliable knock-down for over 10,000 human genes.  Because the human genome is composed of an intricate, genetic network, chimera RNAi's unique design has successfully obviated the off-target effects including microRNA-based influence.  Another advantage of the chimera RNAi technology is its effectiveness at low concentrations (0.5nM to 5nM); only mRNA is destroyed so genomic genes are not affected.  Finally, having both the sense and anti-sense strands consisting RNA/DNA chimera, it offers much greater compound stability for streamlining in vitro and in vivo assays and applications while minimizing interferon induction and other adverse reactions.

Bioinformatics

Product By Gene ID	91662
Alternate Names	FCAS2 Monarch-1 NACHT, leucine rich repeat and PYD containing 12 NACHT, LRR and PYD domains-containing protein 12 NALP12LRR and PYD containing protein 12 NLR family, pyrin domain containing 12 nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domaincontaining 12 PYPAF7Monarch1 PYRIN-containing APAF1-like protein 7 Regulated by nitric oxide RNO2

Research Areas for NALP12

Find related products by research area and learn more about each of the different research areas below.

Apoptosis

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Pyroptosis: Mechanisms mediating cell death and pro-inflammatory cytokine release By Victoria OsinskiPyroptosis is an inflammatory form of programmed cell death characterized by the release of pro-inflammatory cytokines IL-1 beta and IL-18.1,10 It is a process distinct from apoptosis and necrosis (T...    Read more.

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