AF5770
HAF019). A specific band was detected for Mrc2 at approximately 180 kDa (as indicated). This experiment was conducted under reducing conditions and using
Immunoblot Buffer Group 8." class="big_lightbox" target="_blank">
Species: Hu
Applications: WB, IHC
Host: Goat Polyclonal
AF4789
HAF016). A specific band was detected for Mrc2 at approximately 170-180 kDa (as indicated). This experiment was conducted under reducing conditions and using
Immunoblot Buffer Group 8." class="big_lightbox" target="_blank">
Species: Mu
Applications: WB
Host: Sheep Polyclonal
Species: Hu, Rt
Applications: IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: ELISA
Species: Mu
Applications: ELISA
Species: Mu
Applications: ELISA
Species: Hu
Applications: WB
10491-EN
10491-EN) is immobilized at 1 µg/mL (100 µL/well), Recombinant Human Pro-Collagen I alpha 1 (
6220-CL) binds with an ED50 of 0.03-0.36 μg/mL." class="big_lightbox" target="_blank">
![Binding Activity Mrc2 [Unconjugated]](//images.novusbio.com/images/protein/10491-en_recombinant-mouse-mrc2-binding-activity-23620209501.jpg)
10491-EN) was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie® blue staining, showing bands at 145-165 kDa." class="big_lightbox" target="_blank">
![SDS-Page Mrc2 [Unconjugated]]()
Species: Mu
Applications: Bioactivity
10483-EN
10483-EN) is immobilized at 1 µg/mL (100 µL/well), Recombinant Human Pro-Collagen I alpha 1 (
6220-CL) binds with an ED
50 of 0.03-0.36 μg/mL." class="big_lightbox" target="_blank">
![Binding Activity Mrc2 [Unconjugated]](//images.novusbio.com/images/protein/10483-en_recombinant-human-mrc2-his-tag-protein-cf-binding-activity-236202094455.jpg)
10483-EN) was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie® blue staining, showing bands at 155-205 kDa." class="big_lightbox" target="_blank">
![SDS-Page Mrc2 [Unconjugated]]()
Species: Hu
Applications: Bioactivity
Species: Hu
Applications: AC
Description
MRC2, also known as C-type mannose receptor 2, is a 1,479 amino acid protein that is 167 kDa, plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands, may be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface, and may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. Disease research is currently being studied with relations to MRC2 and breast cancer, aortic aneurysm, prostate cancer, progression of osteoarthritis, prostatitis,s, schizophrenia, tuberculosis, immunodeficiency, and hepatitis. Interactions with this protein have shown to involve NDEL1, IL10, TGFB1, TGFB2, TGFB3, and UBC in antigen processing-cross presentation, cross-presentation of soluble exogenous antigens (endosomes), adaptive immune system, class I MHC mediated antigen processing & presentation, immune system, phagosome, and tuberculosis pathways.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
|
| Product By Gene ID |
9902 |
| Alternate Names |
- CD280 antigen
- CD280C-type mannose receptor 2
- CLEC13EUPAR-associated protein
- ENDO180C-type lectin domain family 13 member E
- Endocytic receptor 180
- KIAA0709FLJ35911
- Macrophage mannose receptor 2
- mannose receptor, C type 2
- UPARAPendocytic receptor (macrophage mannose receptor family)
- urokinase plasminogen activator receptor-associated protein
- Urokinase receptor-associated protein
- Urokinase-type plasminogen activator receptor-associated protein
|
![Binding Activity Mrc2 [Unconjugated]](http://images.novusbio.com/images/protein/10491-en_recombinant-mouse-mrc2-binding-activity-23620209501.jpg)
![Binding Activity Mrc2 [Unconjugated]](http://images.novusbio.com/images/protein/10483-en_recombinant-human-mrc2-his-tag-protein-cf-binding-activity-236202094455.jpg)
![SDS-Page Mrc2 [Unconjugated]](http://images.novusbio.com/images/protein/10491-en_recombinant-mouse-mrc2-sds-page-2752020113913.jpg)
![SDS-Page Mrc2 [Unconjugated]](http://images.novusbio.com/images/protein/10483-en_recombinant-human-mrc2-2752020112718.jpg)
