Species: Hu, Mu, Rt, Po
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Rt
Applications: WB, Simple Western, Flow, ICC/IF, IP
Host: Rabbit Polyclonal
Species: Hu
Applications: AC
Description
Lysyl oxidase (LOX) is a critical enzyme in extracellular matrix biosynthesis as well as in the maintainance of normal bone phenotype. It is synthesized/secreted as a 50-kD proenzyme 'pro-LOX' which is then processed to 30-kD mature enzyme 'LOX' and 18-kD lysyl oxidase propeptide 'LOX-PP' by extracellular procollagen C-proteinases (BMP1, Tll1, and Tll2). LOX-PP has been proposed to implicate in the maintenance of inactive state of LOX within the secretory pathway and to act as intramolecular chaperones which facilitate the accurate protein folding/targeting to correct destinations. LOX-PP involves tumor suppression by inhibiting RAS-dependent cellular transformation and its expression has also been associated with inhibition of anchorage-independent progression as well as migration and growth suppression xenografts in Her-2/neu-driven breast cancer. LOX-PP also inhibits PI3K/AKT and ERK1/2 MAP kinase pathways, as well as the levels of downstream NF-kB/cyclin D1 signals in certain cancers - breast, pancreatic, lung, prostate and oral cancers. LOX-PP has also been shown to inhibit DNA synthesis in rat's VSMCs cultures, osteoblast proliferation and FGF-2 signaling.
Bioinformatics
| Entrez |
Human
Mouse
|
| Uniprot |
Human
Mouse
|
| Product By Gene ID |
4015 |
| Alternate Names |
- lysyl oxidaseEC 1.4.3.13
- MGC105112
- protein-lysine 6-oxidase
|
Research Areas for LOX propeptide
Find related products by research area and learn more about each of the different research areas below.
CancerHypoxia
