ILK Products

Description

Integrin-linked kinase (ILK) is a key cytoplasmic plaque protein involved in the mediation of integrin functions. It plays a key role as a regulator during cell survival, cell proliferation, cell migration, and cell to cell adhesion (1). ILK links integrins to the actin cytoskeleton, allowing transduction of signals through integrins to the extracellular matrix (ECM). Also, ILK has been linked to the regulation of smooth contraction and cell motility in non-muscle cells through phosphorylation of myosin (2). Irregular activity level of ILK has been linked to expression of certain tumor. ILK overexpression caused by inactivating mutation in tumor suppressors (e.g. PTEN and APC) lead to tumor formation in transgenic mouse. Up-regulated ILK expression and activity are seen in Ewings scaromas, colorectal cancers, and late staged prostate cancers (3).

Bioinformatics

Entrez	16202 Mouse 170922 Rat 3611 Human
Uniprot	AAH01554 Human NM_001014794 Human NM_004517 Human NP_001014794.1 Human NP_001014795 Human NP_004508 Human NP_004508.1 Human P57043 Human Q13418 Human
Product By Gene ID	3611
Alternate Names	59 kDa serine/threonine-protein kinase DKFZp686F1765 EC 2.7.11.1 ILK1 ILK-1 ILK2 ILK-2 integrin-linked kinase integrin-linked kinase-2 integrin-linked protein kinase P59 p59ILK

Research Areas for ILK

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Protein Kinase
Signal Transduction

Related ILK Blog Posts

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Inhibitor kappa B-alpha (IkappaB-alpha) The transcription factor nuclear factor kappa beta (NFkB) is highly regulated by triggers such as stress, free-radicals, UV light, and hypoxia. NFkB is one of the fastest responding transcription factors in humans. The NFKB signaling pathway is ess...    Read more.

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