Flt-3/Flk-2/CD135 Products

Description

Stem cell tyrosine kinase (STK-1) has been cloned from a CD34+ hematopoietic stem cell enriched library and identified as the human homolog of a previously identified gene of mouse origin designated either Flk-2 or Flt-3. The STK-1 cDNA encodes a protein of 993 amino acids with 85% identity to Flt-3/Flk-2. STK-1 is a member of the type III receptor tyrosine kinase family that includes Kit (steel factor receptor), Fms and PDGF. STK-1 expression in blood and marrow is restricted to CD34+ cells, a population greatly enriched for hematopoietic stem/progenitor cells. STK-1 antiserum recognizes two polypeptides in these cells. The mouse homolog of STK-1, designated Flt-3/ Flk-2, is expressed at high levels in hematopoietic cells and also in neural, gonadal, hepatic and placental tissues. It has been suggested that STK-1 and its murine homolog Flt-3/ Flk-2 may function as growth factor receptors on hematopoietic stem and/or progenitor cells.

Bioinformatics

Entrez	2322 Human
Uniprot	NM_004119 Human NP_004110 Human P06241 Human P36888 Human
Product By Gene ID	2322
Alternate Names	CD135 antigen CD135 EC 2.7.10 fetal liver kinase 2 FL cytokine receptor FLK2 FLT3 receptor tyrosine kinase FLT-3 Fms-like tyrosine kinase 3 fms-related tyrosine kinase 3 growth factor receptor tyrosine kinase type III Stem cell tyrosine kinase 1 STK-1 STK1EC 2.7.10.1 Tyrosine-protein kinase receptor FLT3

Research Areas for Flt-3/Flk-2/CD135

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Phospho-Specific