ErbB3/Her3 Research Products: Novus Biologicals

ErbB3/Her3 Antibodies (57)

ErbB3/Her3 Antibody Pairs (2)

ErbB3/Her3 ELISA Kits (7)

ErbB3/Her3 Lysates (3)

ErbB3/Her3 Proteins (7)

Antibodies

ErbB3/Her3 Antibody (66223) [ ...

MAB3481

377-HB) stimulates proliferation in the MCF-17 human breast cancer cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Human NRG1-1 beta 1/HRG1-1 beta 1 (10 ng/mL) is neutralized (green line) by increasing concentrations of Human ErbB3/Her3 Monoclonal Antibody (Catalog # MAB3481). The ND₅₀ is typically 0.0075-0.03 µg/mL." class="big_lightbox" target="_blank"> Neutralization ErbB3/Her3 Antibody (66223) [Unconjugated]

Neutralization ErbB3/Her3 Antibody (66223) [Unconjugated]

348-RB) was serially diluted and captured by Mouse Anti-Human ErbB3/Her3 Monoclonal Antibody (Catalog # MAB3481) coated on a Clear Polystyrene Microplate (Catalog # DY990). Mouse Anti-Human ErbB3/Her3 Biotinylated Monoclonal Antibody (Catalog # [[catalogNumber:) was incubated with the protein captured on the plate. Detection of the standard curve was achieved by incubating Streptavidin-HRP (Catalog # [[catalogNumber:DY998)" class="big_lightbox" target="_blank"> ELISA ErbB3/Her3 Antibody (66223) [Unconjugated]

ELISA ErbB3/Her3 Antibody (66223) [Unconjugated]

(21 Publications)

Species: Hu
Applications: Flow, B/N, CyTOF-ready, ELISA(Cap)
Host: Mouse Monoclonal

Conjugate	Catalog #	Availability	Size	Price
Alexa Fluor 350	FAB3481U-100UG
Alexa Fluor 405	FAB3481V-100UG
Alexa Fluor 488	FAB3481G-025
Alexa Fluor 488	FAB3481G-100
Alexa Fluor 532	FAB3481X
Alexa Fluor 594	FAB3481T-100UG
Alexa Fluor 647	FAB3481R-100UG
Alexa Fluor 700	FAB3481N-100UG
Alexa Fluor 750	FAB3481S-100UG
Alexa Fluor Plus 405	FAB3481AFP405-100UG
Alexa Fluor Plus 488	FAB3481AFP488-100UG
Alexa Fluor Plus 555	FAB3481AFP555-100UG
Alexa Fluor Plus 594	FAB3481AFP594-100UG
Alexa Fluor Plus 647	FAB3481AFP647-100UG
Alexa Fluor Plus 680	FAB3481AFP680-100UG
Allophycocyanin	FAB3481A-025
Allophycocyanin	FAB3481A-100
Allophycocyanin/Cy7	FAB3481APCCY7
Biotin	FAB3481B
CoraFluor 1	FAB3481CL1
DyLight 350	FAB3481D
DyLight 405	FAB3481E
DyLight 488	FAB3481K
DyLight 550	FAB3481L
DyLight 594	FAB3481M
DyLight 650	FAB3481W
DyLight 680	FAB3481Y
DyLight 755	FAB3481Z
FITC	FAB3481F
HRP	FAB3481H
Janelia Fluor 525	FAB3481JF525
Janelia Fluor 549	FAB3481I
Janelia Fluor 646	FAB3481J
Janelia Fluor 669	FAB3481JF669
PE/Atto594	FAB3481PEATT594
PE/Cy5.5	FAB3481PECY55
PE/Cy7	FAB3481PECY7
Phycoerythrin	FAB3481P-025
Phycoerythrin	FAB3481P-100
mFluor Violet 450 SE	FAB3481MFV450
mFluor Violet 500 SE	FAB3481MFV500
mFluor Violet 610 SE	FAB3481MFV610

Formulation	Catalog #	Availability	Price
Carrier Free	MAB3481-SP
Carrier Free	MAB3481-500
Carrier Free	MAB3481-100
Carrier Free	FAB3481A-100
Carrier Free	FAB3481A-025
Carrier Free	FAB3481P-100
Carrier Free	FAB3481P-025
Carrier Free	FAB3481G-100
Carrier Free	FAB3481G-025
Carrier Free	FAB3481V-100UG
Carrier Free	FAB3481U-100UG
Carrier Free	FAB3481T-100UG
Carrier Free	FAB3481S-100UG
Carrier Free	FAB3481R-100UG
Carrier Free	FAB3481N-100UG

ErbB3/Her3 Antibody

AF234

HAF019). A specific band was detected for ErbB3/Her3 at approximately 180kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8." class="big_lightbox" target="_blank"> Western Blot ErbB3/Her3 Antibody

377-HB) stimulates proliferation in the MCF-7 human breast cancer cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Human NRG1-beta 1/HRG1-beta 1 Extracellular Domain (10 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human ErbB3/Her3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF234). The ND₅₀ is typically 0.125-0.5 µg/mL." class="big_lightbox" target="_blank"> Neutralization ErbB3/Her3 Antibody

(9 Publications)

Species: Hu
Applications: WB, Flow, B/N, CyTOF-ready
Host: Goat Polyclonal

Conjugate	Catalog #	Availability	Size	Price
Alexa Fluor 350	AF234U-100UG
Alexa Fluor 405	AF234V-100UG
Alexa Fluor 488	AF234G-100UG
Alexa Fluor 532	AF234X-100UG
Alexa Fluor 594	AF234T-100UG
Alexa Fluor 647	AF234R-100UG
Alexa Fluor 700	AF234N-100UG
Alexa Fluor 750	AF234S-100UG
Alexa Fluor Plus 405	AF234AFP405-100UG
Alexa Fluor Plus 488	AF234AFP488-100UG
Alexa Fluor Plus 555	AF234AFP555-100UG
Alexa Fluor Plus 594	AF234AFP594-100UG
Alexa Fluor Plus 647	AF234AFP647-100UG
Alexa Fluor Plus 680	AF234AFP680-100UG
Allophycocyanin	AF234A
Biotin	BAF234
CoraFluor 1	AF234CL1
DyLight 350	AF234D
DyLight 405	AF234E
DyLight 488	AF234K
DyLight 550	AF234L
DyLight 594	AF234M
DyLight 650	AF234W
DyLight 680	AF234Y
DyLight 755	AF234Z
FITC	AF234F
HRP	AF234H
Janelia Fluor 525	AF234JF525
Janelia Fluor 549	AF234I
Janelia Fluor 646	AF234J
Janelia Fluor 669	AF234JF669
PE	AF234P
PerCP	AF234C
mFluor Violet 450 SE	AF234MFV450
mFluor Violet 500 SE	AF234MFV500
mFluor Violet 610 SE	AF234MFV610

Formulation	Catalog #	Availability	Price
Carrier Free	AF234-SP

ErbB3/Her3 Antibody (66219)

MAB348

(8 Publications)

Species: Hu
Applications: WB, IHC
Host: Mouse Monoclonal

Conjugate	Catalog #	Availability	Size	Price
Alexa Fluor 350	FAB348U-100UG
Alexa Fluor 405	FAB348V-100UG
Alexa Fluor 488	FAB348G-100UG
Alexa Fluor 532	FAB348X-100UG
Alexa Fluor 594	FAB348T-100UG
Alexa Fluor 647	FAB348R-100UG
Alexa Fluor 700	FAB348N-100UG
Alexa Fluor 750	FAB348S-100UG
Alexa Fluor Plus 405	FAB348AFP405-100UG
Alexa Fluor Plus 488	FAB348AFP488-100UG
Alexa Fluor Plus 555	FAB348AFP555-100UG
Alexa Fluor Plus 594	FAB348AFP594-100UG
Alexa Fluor Plus 647	FAB348AFP647-100UG
Alexa Fluor Plus 680	FAB348AFP680-100UG
Allophycocyanin	FAB348A
Biotin	FAB348B
CoraFluor 1	FAB348CL1
DyLight 350	FAB348D
DyLight 405	FAB348E
DyLight 488	FAB348K
DyLight 550	FAB348L
DyLight 594	FAB348M
DyLight 650	FAB348W
DyLight 680	FAB348Y
DyLight 755	FAB348Z
FITC	FAB348F
HRP	FAB348H
Janelia Fluor 525	FAB348JF525
Janelia Fluor 549	FAB348I
Janelia Fluor 646	FAB348J
Janelia Fluor 669	FAB348JF669
PE	FAB348P
PerCP	FAB348C
mFluor Violet 450 SE	FAB348MFV450
mFluor Violet 500 SE	FAB348MFV500
mFluor Violet 610 SE	FAB348MFV610

Formulation	Catalog #	Availability	Price
Carrier Free	MAB348-SP
Carrier Free	MAB348-500
Carrier Free	MAB348-100

We have 57 ErbB3/Her3 Antibodies

Antibody Pairs

ErbB3/Her3 Antibody Pair [HRP ...

NBP2-79511

Species: Hu
Applications: ELISA
Host: Monoclonal

Conjugate	Catalog #	Availability	Size	Price
HRP	NBP2-79511-5Plates
HRP	NBP2-79511-15Plates

ErbB3/Her3 Antibody Pair [HRP ...

NBP2-79607

Species: Mu
Applications: ELISA
Host: Rabbit Monoclonal

Conjugate	Catalog #	Availability	Size	Price
HRP	NBP2-79607-5Plates
HRP	NBP2-79607-15Plates

We have 2 ErbB3/Her3 Antibody Pairs

ELISA Kits

Human Phospho-ErbB3/Her3 DuoS ...

DYC1769-2

396-HB) for five minutes to induce tyrosine phosphorylation of ErbB3. Serial dilutions of lysates were analyzed by R&D Systems’ Phospho-ErbB3 DuoSet IC ELISA (Catalog # DYC1769) and by IP-Western blot (inset). For IP-Westerns, IPs were done using anti-ErbB3 monoclonal antibody and anti-mouse IgG agarose. Immunoblots were incubated with biotinylated anti-phosphotyrosine monoclonal antibody (Cat # BAM1676) to detect phospho-ErbB3. Bands were visualized with Streptavidin-HRP (Cat # DY998) followed by ECL detection. ErbB3 was observed at its predicted size (inset; 185 kDa, arrow) in Western blot analysis." class="big_lightbox" target="_blank"> ELISA ErbB3/Her3 [Biotin]

396-HB) for five minutes. Cell lysates (100 μg) were analyzed by R&D Systems’ Phospho-ErbB3 DuoSet IC ELISA (Catalog # DYC1769) and by IP-Western blot (inset). IP-Western blots for phospho-ErbB3 (p-ErbB3) were done as described in Figure 1. Blots were stripped and total ErbB3 (ErbB3) was detected using biotinylated anti-ErbB3 polyclonal antibody (Catalog # BAF234). " class="big_lightbox" target="_blank"> ELISA ErbB3/Her3 [Biotin]

396-HB) for five minutes. The indicated amounts of ErbB3 (Catalog # 348-ER), ErbB2 (Catalog # 1129-ER) or EGF R (Catalog # 1095-ER) recombinant extracellular domains were added to 5 μg lysate and analyzed using R&D Systems’ Human Phospho-ErbB3 DuoSet IC ELISA (Catalog # DYC1769). Competition was observed only with recombinant ErbB3. " class="big_lightbox" target="_blank"> ELISA ErbB3/Her3 [Biotin]

(4 Publications)

Species: Hu
Applications: ELISA

Conjugate	Catalog #	Availability	Size	Price
Biotin	DYC1769E
Biotin	DYC1769-5

Human ErbB3/Her3 DuoSet ELISA ...

DY348

(4 Publications)

Species: Hu
Applications: ELISA

Human Total ErbB3/Her3 DuoSet ...

DYC234-2

(4 Publications)

Species: Hu
Applications: ELISA

Conjugate	Catalog #	Availability	Size	Price
Biotin	DYC234-5

We have 7 ErbB3/Her3 ELISA Kits

Lysates

ErbB3/Her3 Overexpression Lys ...

NBP2-08854

Species: Hu
Applications: WB

ErbB3/Her3 Overexpression Lys ...

NBP2-04209

Species: Hu
Applications: WB

ErbB3/Her3 Overexpression Lys ...

NBP2-09102

Species: Hu
Applications: WB

We have 3 ErbB3/Her3 Lysates

Proteins

Recombinant Human ErbB3/Her3 ...

348-RB

(12 Publications)

Species: Hu
Applications: Bioactivity

Formulation	Catalog #	Availability	Price
Carrier Free	348-RB-050

Recombinant Mouse ErbB3/Her3 ...

4518-RB

(2 Publications)

Species: Mu
Applications: Binding Activity

Formulation	Catalog #	Availability	Price
Carrier Free	4518-RB-050

Recombinant Human ErbB3/Her3 ...

10368-RB

377-HB) on MCF-7 human breast cancer cells. The ED50 for this effect is 0.3-3 µg/mL." class="big_lightbox" target="_blank"> Bioactivity ErbB3/Her3 [Unconjugated]

Species: Hu
Applications: Bioactivity

Formulation	Catalog #	Availability	Price
Carrier Free	10368-RB-050

We have 7 ErbB3/Her3 Proteins

Description

The ErbB3 gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized.

Bioinformatics

Entrez	13867 Mouse 2065 Human 29496 Rat
Uniprot	AAH02706 Human AAH02706.1 Human NP_001005915 Human NP_001973 Human NP_001973.2 Human P21860 Human
Product By Gene ID	2065
Alternate Names	c-erbB3 EC 2.7.10 EC 2.7.10.1 ErbB-3 erbB3-S HER3c-erbB-3 LCCS2 lethal congenital contracture syndrome 2 MDA-BF-1 MGC88033 p180-ErbB3 p45-sErbB3 p85-sErbB3 Proto-oncogene-like protein c-ErbB-3 receptor tyrosine-protein kinase erbB-3 Tyrosine kinase-type cell surface receptor HER3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

Research Areas for ErbB3/Her3

Find related products by research area and learn more about each of the different research areas below.

Cancer
Phospho-Specific
Protein Kinase
Tumor Suppressors

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ErbB3/Her3 Products

Description

Bioinformatics

Research Areas for ErbB3/Her3

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