CRM1 Products

Description

Official Gene Symbol: XPO1 Gen Bank Accession Number: NP_003391 Gene ID: 7514 (human) Gene Map Locus: 2p16 (human) Nuclear transport receptors of karyopherin/importin-beta superfamily mediate various transport pathways between nucleus and cytoplasm. Exportin-1, a human homolog of yeast CRM1, is a novel karyopherin export receptor that mediates leucine-rich NES-dependent protein export. It interacts with RanGTP through its Ran-binding domain and also with nucleoporins including Nup214, Nup50, Nup42 and Nup159 during the process of exporting NES-containing proteins. It mediates the export of many cellular and viral proteins and ribonucleoproteins including HIV Rev Protein, ERK3, PKI, IRF-5, Cyclin-B, MAPKK, MAPKAP kinase 2, Snurportin, Cap-binding protein, and certain U snRNAs. Reports suggest exportin-1 also has a role in the regulation of NFAT and AP-1.

Bioinformatics

Entrez	103573 Mouse 7514 Human 85252 Rat
Uniprot	AAH32847.1 Human NP_003391 Human NP_003391.1 Human O14980 Human
Product By Gene ID	7514
Alternate Names	Chromosome region maintenance 1 protein homolog DKFZp686B1823 emb Exp1 exp1 exportin 1 (CRM1 homolog, yeast) exportin 1 (CRM1, yeast, homolog) Exportin-1 (required for chromosome region maintenance) exportin-1 yeast, homolog

Research Areas for CRM1

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Core ESC-Like Genes
Stem Cell Markers

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