Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Monoclonal
Species: Hu
Applications: IP, WB (-)
Host: Rabbit Polyclonal
Species: Hu
Applications: ELISA, IHC
Host: Rabbit Monoclonal
Species: Hu
Applications: ELISA
Description
Official Gene Symbol: XPO1 Gen Bank Accession Number: NP_003391 Gene ID: 7514 (human) Gene Map Locus: 2p16 (human) Nuclear transport receptors of karyopherin/importin-beta superfamily mediate various transport pathways between nucleus and cytoplasm. Exportin-1, a human homolog of yeast CRM1, is a novel karyopherin export receptor that mediates leucine-rich NES-dependent protein export. It interacts with RanGTP through its Ran-binding domain and also with nucleoporins including Nup214, Nup50, Nup42 and Nup159 during the process of exporting NES-containing proteins. It mediates the export of many cellular and viral proteins and ribonucleoproteins including HIV Rev Protein, ERK3, PKI, IRF-5, Cyclin-B, MAPKK, MAPKAP kinase 2, Snurportin, Cap-binding protein, and certain U snRNAs. Reports suggest exportin-1 also has a role in the regulation of NFAT and AP-1.
Bioinformatics
| Product By Gene ID |
7514 |
| Alternate Names |
- Chromosome region maintenance 1 protein homolog
- DKFZp686B1823
- emb
- exp1
- exportin 1 (CRM1 homolog, yeast)
- exportin 1 (CRM1, yeast, homolog)
- Exportin-1 (required for chromosome region maintenance)
- exportin-1
- yeast, homolog
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