ZAP70 Products

Description

Zap-70, a Syk-family protein tyrosine kinase, plays a critical role in mediating T cell signal transduction in response to T cell receptor (TCR) activation (1). TCR-mediated activation of the Src-family kinases, Lck and Fyn, results in tyrosine phosphorylation of the TCR zeta and CD3 chains. These domains serve as targets for binding of ZAP-70 via its tandem SH2 domains. This binding correlates with activation of ZAP-70, a critical event in T cell activation (2). Following TCR engagement, ZAP-70 is phosphorylated on several tyrosine residues, presumably by two mechanisms: an autophosphorylation and a trans-phosphorylation by the Src-family tyrosine kinase, Lck. Phosphorylation of Tyr319 is required for full activation and increased positive downstream regulation by ZAP-70 (3).

Bioinformatics

Entrez	22637 Mouse 301348 Rat 7535 Human
Uniprot	AAH39039 Human AAH53878.1 Human NM_001079 Human NP_001070 Human NP_001070.2 Human P43403 Human
Product By Gene ID	7535
Alternate Names	70 kDa zeta-associated protein EC 2.7.10 EC 2.7.10.2 SRKFLJ17679 STDFLJ17670 Syk-related tyrosine kinase tyrosine-protein kinase ZAP-70 TZK ZAP-70 zeta-chain (TCR) associated protein kinase (70 kD) zeta-chain (TCR) associated protein kinase 70kDa zeta-chain associated protein kinase, 70kD

Research Areas for ZAP70

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
CD Markers
Cell Biology
Immunology
Phospho-Specific
Protein Kinase
Signal Transduction
Tyrosine Kinases