ZAP70 Products

Antibodies
ZAP70 Antibody (3D2A4)
ZAP70 Antibody (3D2A4)
NB110-60490
Species: Hu
Applications: WB, ELISA, IHC, IHC-P
Host: Mouse Monoclonal
ZAP70 Antibody
ZAP70 Antibody
NBP1-87000
Species: Hu
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
ZAP70 Antibody
ZAP70 Antibody
AF6375
Species: Hu
Applications: WB, IHC
Host: Sheep Polyclonal
Lysates
ZAP70 Overexpression Lysate ( ...
ZAP70 Overexpression Lysate (Native)
NBP2-08469
Applications: WB
ZAP70 Overexpression Lysate ( ...
ZAP70 Overexpression Lysate (Denat...
H00007535-T02
Species: Hu
Applications: WB
Proteins
ZAP70 Recombinant Protein Ant ...
ZAP70 Recombinant Protein Antigen
NBP1-87000PEP
Species: Hu
Applications: AC
Recombinant Human ZAP70 Prote ...
Recombinant Human ZAP70 Protein
P4235
Species: Hu
Applications: Func, PAGE
Recombinant ZAP70 Protein
Recombinant ZAP70 Protein
NBP1-99479
RNAi
ZAP70 RNAi
ZAP70 RNAi
H00007535-R04
Species: Hu
Applications: RNAi, RNAi SP
ZAP70 RNAi
ZAP70 RNAi
H00007535-R03
Species: Hu
Applications: RNAi, RNAi SP

Description

Zap-70, a Syk-family protein tyrosine kinase, plays a critical role in mediating T cell signal transduction in response to T cell receptor (TCR) activation (1). TCR-mediated activation of the Src-family kinases, Lck and Fyn, results in tyrosine phosphorylation of the TCR zeta and CD3 chains. These domains serve as targets for binding of ZAP-70 via its tandem SH2 domains. This binding correlates with activation of ZAP-70, a critical event in T cell activation (2). Following TCR engagement, ZAP-70 is phosphorylated on several tyrosine residues, presumably by two mechanisms: an autophosphorylation and a trans-phosphorylation by the Src-family tyrosine kinase, Lck. Phosphorylation of Tyr319 is required for full activation and increased positive downstream regulation by ZAP-70 (3).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 7535
Alternate Names
  • EC 2.7.10
  • EC 2.7.10.2
  • zeta-chain associated protein kinase, 70kD
  • 70 kDa zeta-associated protein
  • tyrosine-protein kinase ZAP-70
  • Syk-related tyrosine kinase
  • TZK
  • ZAP-70
  • SRKFLJ17679
  • STDFLJ17670
  • zeta-chain (TCR) associated protein kinase (70 kD)
  • zeta-chain (TCR) associated protein kinase 70kDa

Research Areas for ZAP70

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
CD Markers
Cell Biology
Immunology
Phospho-Specific
Protein Kinase
Signal Transduction
Tyrosine Kinases

Bioinformatics Tool for ZAP70

Discover related pathways, diseases and genes to ZAP70. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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