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HAF007). A specific band was detected for VRK1 at approximately 54 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_lightbox" target="_blank">
VC001). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm and nuclei of sperm cells. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents." class="big_lightbox" target="_blank">
Species: Hu Applications: WB, IHC, ICC/IF Host: Mouse Monoclonal
VRK1 encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.
![Western Blot VRK1 Antibody (1F6) [Unconjugated]](http://images.novusbio.com/images/antibody/VRK1_MAB5835_Western_Blot_6265.jpg)
![Immunocytochemistry VRK1 Antibody (1F6) [Unconjugated]](http://images.novusbio.com/images/antibody/VRK1_MAB5835_Immunocytochemistry__Immunofluorescence_20272.jpg)
![Immunohistochemistry VRK1 Antibody (1F6) [Unconjugated]](http://images.novusbio.com/images/antibody/VRK1_MAB5835_Immunohistochemistry_20601.jpg)
