VRK1 Products

Description

VRK1 encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.

Bioinformatics

Entrez	7443 Human
Uniprot	NM_003384 Human NP_003375 Human NP_003375.1 Human Q99986 Human
Product By Gene ID	7443
Alternate Names	EC 2.7.11.1 MGC117401 MGC138280 MGC142070 PCH1 serine/threonine-protein kinase VRK1 vaccinia related kinase 1 vaccinia virus B1R-related kinase 1 Vaccinia-related kinase 1

Research Areas for VRK1

Find related products by research area and learn more about each of the different research areas below.

Core ESC-Like Genes
Protein Kinase
Stem Cell Markers