USP14 Products

Description

USP14 encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Bioinformatics

Entrez	59025 Mouse 9097 Human
Uniprot	AAH03556 Human NM_005151 Human NP_005142 Human NP_005142.1 Human P54578 Human UB14_HUMAN Human
Product By Gene ID	9097
Alternate Names	Deubiquitinating enzyme 14 EC 3.1.2.15 EC 3.4.19.12 TGT TGTubiquitin carboxyl-terminal hydrolase 14 tRNA-guanine transglycosylase, 60-kD subunit ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) ubiquitin specific protease 14 (tRNA-guanine transglycosylase) ubiquitin thioesterase 14 Ubiquitin thiolesterase 14 ubiquitin-specific processing protease 14 Ubiquitin-specific-processing protease 14

Research Areas for USP14

Find related products by research area and learn more about each of the different research areas below.

Protein Turnover
Ubiquitin Proteasome Pathway