UGT1A6 Products

Description

UGT1A6 encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants.

Bioinformatics

Entrez	54578 Human
Uniprot	AAH19861.1 Human NM_001072 Human NP_001063 Human P19224 Human
Product By Gene ID	54578
Alternate Names	GNT1UDPGT 1-6 HLUGP HLUGP1 MGC29860 Phenol-metabolizing UDP-glucuronosyltransferase UDP glucuronosyltransferase 1 family, polypeptide A6 UDP glycosyltransferase 1 family, polypeptide A6 UDP-glucuronosyltransferase 1 family polypeptide A6s UDP-glucuronosyltransferase 1-6 UDP-glucuronosyltransferase 1A6 UDP-glucuronosyltransferase 1-F UDPGT UGT1 UGT1*6 UGT1.6 UGT1-06 UGT1A6S UGT-1F UGT1FEC 2.4.1.17

Research Areas for UGT1A6

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Cancer