Species: Hu, Mu, Bv, Pm-Or
Applications: WB, IHC, IP
Host: Rabbit Polyclonal
Species: Hu, Mu, Pm, RM
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
Species: Hu, Mu, Ze, Po, Bv, Ch, RM, Xp
Applications: WB, ICC/IF, IHC, IP
Host: Rabbit Polyclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu, Mu, Rt
Applications: Enzyme Activity
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. UBCH7 catalyzes the covalent attachment of ubiquitin to other proteins and mediates the selective degradation of short-lived and abnormal proteins as well as playing a role in the E6/E6-AP-induced ubiquitination of p53/TP53. Expression of this protein is ubiquitous, with highest expression in testis.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
|
| Product By Gene ID |
7332 |
| Alternate Names |
- E2-F1
- EC 6.3.2.19
- L-UBC
- UBCE7
- UbcH7
- UBCH7UbcM4
- UbcM4
- UBE2L3
- Ubiquitin carrier protein L3
- ubiquitin-conjugating enzyme E2 L3
- Ubiquitin-conjugating enzyme E2-F1
- ubiquitin-conjugating enzyme E2L 3
- ubiquitin-conjugating enzyme UBCH7
- Ubiquitin-protein ligase L3
|
