UbcH5b/UBE2D2 Products

Description

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.

Bioinformatics

Entrez	7322 Human
Uniprot	NM_003339 Human NM_181838 Human NP_003330 Human NP_003330.1 Human P62837 Human
Product By Gene ID	7322
Alternate Names	E2(17)KB2 EC 6.3.2.19 PUBC1 UBC4/5 UBC4ubiquitin-conjugating enzyme E2D 2 (homologous to yeast UBC4/5) UBC5B UBCH4 UbcH5B UBCH5B Ubiquitin carrier protein D2 ubiquitin-conjugating enzyme E2 D2 Ubiquitin-conjugating enzyme E2(17)KB 2 Ubiquitin-conjugating enzyme E2-17 kDa 2 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) Ubiquitin-protein ligase D2

Research Areas for UbcH5b/UBE2D2

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Cancer
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