TSC2 Products

Antibodies
TSC2 Antibody (614204) [Uncon ...
TSC2 Antibody (614204) [Unconjugated]
MAB40401
Species: Hu, Mu
Applications: WB, IHC, ICC
Host: Mouse Monoclonal
TSC2 Antibody
TSC2 Antibody
NBP1-82849
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
TSC2 Antibody
TSC2 Antibody
AF4040
Species: Hu
Applications: WB, IHC
Host: Sheep Polyclonal
Proteins
TSC2 Recombinant Protein Anti ...
TSC2 Recombinant Protein Antigen
NBP2-56083PEP
Species: Hu
Applications: B/N, Ctrl
Recombinant Human TSC2 Protei ...
Recombinant Human TSC2 Protein
H00007249-Q01
Species: Hu
Applications: WB, ELISA, PA
TSC2 Recombinant Protein Anti ...
TSC2 Recombinant Protein Antigen
NBP1-82849PEP
Species: Hu
Applications: AC
RNAi
TSC2 RNAi
TSC2 RNAi
H00007249-R01
Species: Hu
Applications: RNAi, RNAi SP
TSC2 RNAi
TSC2 RNAi
H00007249-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

Tuberous sclerosis complex-2 (TCS2 also known as Tuberin) is a tumor suppressor that forms a complex with TSC1 (Hamartin ) and this complex is known to control various cellular functions including cell cycle, endocytosis, adhesion, and transcription (1). The C-terminal region of TSC2 contains a GTPase-activating protein (GAP) domain which interacts with Rap1, Rab5 and Rheb (2). The TSC1/TSC2 complex inhibits phosphorylation of S6kinase and 4E-BP1 through inactivation of mTOR (3). Additionally, binding of 14-3-3 beta to TSC2 at Ser1210 reduce the ability of the complex to inhibit phosphorylation of S6 kinase (4). Phosphorylation by ATK at Ser924 and Thr1518 inactivates TSC2 and disrupts its interaction with TSC1 (5). Tuberous sclerosis (TSC), an autosomal dominant disorder that affects 1 in 6000 individuals, is caused by a mutation in either the TSC1 or TSC2 tumor suppressor gene.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Product By Gene ID 7249
Alternate Names
  • Tuberous sclerosis 2 protein
  • tuberin
  • LAMFLJ43106
  • TSC4
  • tuberous sclerosis 2

Research Areas for TSC2

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Autophagy
Cancer
Cell Cycle and Replication
Cytoskeleton Markers
Hypoxia
mTOR Pathway
Phospho-Specific
Signal Transduction
Tumor Suppressors

Bioinformatics Tool for TSC2

Discover related pathways, diseases and genes to TSC2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related TSC2 Blog Posts

Check out the latest blog posts on TSC2.
TSC2 - GTPase activating protein involved in cell cycle inhibition
TSC2 is a tumor suppressor gene that encodes a 200 kDa protein called tuberin. TSC2 heterodimerizes with TSC1 to form a complex with GTPase-activating protein (GAP) activity. The C-terminus of TSC2 contains the GAP domain responsible for this cata...    Read more.
Read more TSC2 related blogs.