Species: Hu, Mu, Rt, Rb
Applications: WB, IHC
Host: Rabbit Monoclonal
Species: Hu, Mu, Rt, Rb
Applications: WB, IHC
Host: Rabbit Monoclonal
Species: Hu, Mu, Rt, Bv, Ca
Applications: WB, ELISA, IHC
Host: Goat Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, PAGE, AP
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of therepair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membranedamage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization atthe injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to theinjury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealingprocess. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membranebudding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (Bysimilarity)
Bioinformatics
| Entrez |
Rat
Mouse
Human
|
| Uniprot |
Human
Human
Human
|
| Product By Gene ID |
493829 |
| Alternate Names |
- MG53Mg53
- mitsugumin-53
- Mitsugumin-53
- tripartite motif containing 72
- tripartite motif-containing 72
- tripartite motif-containing protein 72
|
Research Areas for TRIM72
Find related products by research area and learn more about each of the different research areas below.
Zinc Finger
