TRIAD3 Products

Description

The TRIAD3 gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known.

Bioinformatics

Entrez	108086 Mouse 54476 Human
Uniprot	Q9NWF9 Human
Product By Gene ID	54476
Alternate Names	EC 6.3.2.- ring finger protein 216Ubiquitin-conjugating enzyme 7-interacting protein 1 Triad domain-containing protein 3 TRIAD3Zinc finger protein inhibiting NF-kappa-B U7I1 UBCE7IP1ubiquitin conjugating enzyme 7 interacting protein 1 ZINE3 ubiquitin-protein ligase RNF216