TRERF1 Products

Description

Chimera RNA interference (chimera RNAi) is process by which small interfering RNA/DNA chimera triggers the destruction of mRNA for the original gene.  The discovery work, design, and application of chimera RNAi has been pioneered by Professor Kaoru Saigo and Dr. Kumiko Ui-Tei at the University of Tokyo.  Chimera RNAi has many advantages over the conventional siRNAs.  First, it has been demonstrated to have reliable knock-down for over 10,000 human genes.  Because the human genome is composed of an intricate, genetic network, chimera RNAi's unique design has successfully obviated the off-target effects including microRNA-based influence.  Another advantage of the chimera RNAi technology is its effectiveness at low concentrations (0.5nM to 5nM); only mRNA is destroyed so genomic genes are not affected.  Finally, having both the sense and anti-sense strands consisting RNA/DNA chimera, it offers much greater compound stability for streamlining in vitro and in vivo assays and applications while minimizing interferon induction and other adverse reactions.

Bioinformatics

Product By Gene ID	55809
Alternate Names	BCAR2 Breast cancer estrogen resistance 2RAPAHSA277276 dJ139D8.5 FLJ21198 rapa-1 rapa-2 RP1-139D8.5 transcriptional regulating factor 1 transcriptional regulating protein 132 transcriptional-regulating factor 1 Transcriptional-regulating protein 132 TREP132 TReP-132 Zinc finger protein rapa Zinc finger transcription factor TReP-132