TopBP1 Products

Antibodies
TopBP1 Antibody
TopBP1 Antibody
Species: Hu, Mu
Applications: WB, IP
Host: Rabbit Polyclonal
TopBP1 Antibody
TopBP1 Antibody
AF7120
Species: Hu
Applications: IHC
Host: Sheep Polyclonal
Formulation Catalog # Availability Price  
TopBP1 Antibody (6D12)
TopBP1 Antibody (6D12)
H00011073-M04-100ug
Species: Hu
Applications: WB, ELISA, S-ELISA
Host: Mouse Monoclonal
Lysates
TopBP1 Overexpression Lysate
TopBP1 Overexpression Lysate
NBP2-07543
Species: Hu
Applications: WB
Proteins
Recombinant Human TopBP1 GST ...
Recombinant Human TopBP1 GST (N-Te...
H00011073-Q01
Species: Hu
Applications: WB, ELISA, PA, AP
TopBP1 Recombinant Protein An ...
TopBP1 Recombinant Protein Antigen
NBP2-55483PEP
Species: Hu
Applications: AC
TopBP1 Recombinant Protein An ...
TopBP1 Recombinant Protein Antigen
NBP2-55484PEP
Species: Hu
Applications: AC

Description

DNA topoisomerase II-binding protein 1 (TopBP1) is a protein that interacts with the C-terminal region of topoisomerase II beta (Topo II beta). TopBP1 function has been found to be important to various aspects of cellular growth control such as DNA replication, the DNA damage checkpoint, and cell survival. TopBP1 interacts with several proteins through its BRCA1 C-terminal (BRCT) motifs. TopBP1 interacts and inhibits E2F1 transcriptional activity through an Rb-independent mechanism that involves recruitment of the SWI/SNF chromatin-remodeling complex proteins Brg1 and Brm.

Bioinformatics

Entrez Human
Uniprot Human
Human
Product By Gene ID 11073
Alternate Names
  • DNA topoisomerase II-beta-binding protein 1
  • TopBP1
  • TOP2BP1
  • KIAA0259DNA topoisomerase 2-binding protein 1
  • DNA topoisomerase II-binding protein 1
  • topoisomerase (DNA) II binding protein 1

PTMs for TopBP1

Learn more about PTMs related to TopBP1.

Phosphorylation
Methylation
Ubiquitination
Glycosylation
Deacetylation
Ribosylation

Bioinformatics Tool for TopBP1

Discover related pathways, diseases and genes to TopBP1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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