TopBP1 Products

Antibodies
TopBP1 Antibody
TopBP1 Antibody
Species: Hu, Mu, Primate
Applications: WB, IP, PLA
Host: Rabbit Polyclonal
TopBP1 Antibody
TopBP1 Antibody
AF7120
Species: Hu
Applications: IHC
Host: Sheep Polyclonal
TopBP1 Antibody (6D12)
TopBP1 Antibody (6D12)
H00011073-M04-100ug
Species: Hu
Applications: WB, ELISA
Host: Mouse Monoclonal
Lysates
TopBP1 Overexpression Lysate ...
TopBP1 Overexpression Lysate (Native)
NBP2-07543
Applications: WB
Proteins
TopBP1 Partial Recombinant Pr ...
TopBP1 Partial Recombinant Protein
H00011073-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
TopBP1 RNAi
TopBP1 RNAi
H00011073-R01
Species: Hu

Description

DNA topoisomerase II-binding protein 1 (TopBP1) is a protein that interacts with the C-terminal region of topoisomerase II beta (Topo II beta). TopBP1 function has been found to be important to various aspects of cellular growth control such as DNA replication, the DNA damage checkpoint, and cell survival. TopBP1 interacts with several proteins through its BRCA1 C-terminal (BRCT) motifs. TopBP1 interacts and inhibits E2F1 transcriptional activity through an Rb-independent mechanism that involves recruitment of the SWI/SNF chromatin-remodeling complex proteins Brg1 and Brm.

Bioinformatics

Entrez Human
Uniprot Human
Human
Product By Gene ID 11073
Alternate Names
  • DNA topoisomerase II-beta-binding protein 1
  • TopBP1
  • TOP2BP1
  • KIAA0259DNA topoisomerase 2-binding protein 1
  • DNA topoisomerase II-binding protein 1
  • topoisomerase (DNA) II binding protein 1

PTMs for TopBP1

Learn more about PTMs related to TopBP1.

Phosphorylation
Methylation
Ubiquitination
Glycosylation
Deacetylation
Ribosylation

Bioinformatics Tool for TopBP1

Discover related pathways, diseases and genes to TopBP1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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