TOB1 Products

Description

TOB1 encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein supresses cell growth in tissue culture. The protein undergoes phophorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells. [provided by RefSeq]

Bioinformatics

Product By Gene ID	10140
Alternate Names	APRO6 MGC104792 PIG49 protein Tob1 TOB1 TOBMGC34446 Transducer of erbB-2 1 transducer of ERBB2, 1 TROB TROB1

Research Areas for TOB1

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Cell Cycle and Replication