TMPRSS11E Products

Description

TMPRSS11E is a member of a larger family of membrane attached serine proteases, a poorly defined group that includes TMPRSS11A, B, C, D, E, F, Hepsin, Corin, Matriptase 1, 2 and 3. The highest degree of identity is with TMPRSS11A, which shares 43% identity at the amino acid level. TMPRSS11E has a domain structure of an aminoterminal cytoplasmic domain, followed by a transmembrane domain, a SEA domain (Sea urchin sperm protein, Enterokinase, Agrin), a short spacer, then the trypsin like serine protease domain. The SEA domain is thought to play a role in carbohydrate binding in the analogous protein sequences where it is found, but the role in TMPRSS11E is unclear. The cleavage of the Arg191 Ile192 bond liberates the catalytic domain. TMPRSS11E has been shown to cleave fibronectin, gelatin, casein and pro uPA in vitro, and to form complexes with serpinA5 and serpinE1.

Bioinformatics

Entrez	28983 Human
Uniprot	NP_054777 Human Q9UL52 Human
Product By Gene ID	28983
Alternate Names	DESC1 FLJ75331 FLJ94490 MGC141972 MGC141974 serine 11E2 serine protease DESC1 TMPRSS11E2 transmembrane protease serine 11E transmembrane protease serine 11E2 transmembrane protease, serine 11E UNQ742/PRO1461