TLK1 Products

Description

Tousled-like kinase 1 (TLK1) is a serine/threonine kinase involved in chromatin assembly and the DNA damage response. The tousled (Tsl) kinase was first identified in Arabidopsis thaliana and speculated to be involved in cell division during patterning of plant organs. There are two tousled-like kinases in humans, TLK1 and TLK2, that can dimerize or heterodimerize for function and can be phosphorylated and inactivated by Chk1 in response to DNA damage. The histone chaperone, Asf1 (anti-silencing function 1), has been reported as a substrate for both TLK1 and TLK2. TLK1 has also been shown to be important for cell cycle progression and proper chromosome segregation.

Bioinformatics

Entrez	9874 Human
Uniprot	AAH32657 Human ABM84983.1 Human NM_012290 Human NP_036422 Human Q9UKI8 Human Q9Y4F6 Human
Product By Gene ID	9874
Alternate Names	EC 2.7.11 EC 2.7.11.1 KIAA0137serine/threonine-protein kinase tousled-like 1 PKU-BETA PKU-beta SNARE protein kinase SNAK tousled-like kinase 1serine threonine protein kinase

Research Areas for TLK1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Cycle and Replication
Checkpoint signaling
Chromatin Research
DNA Repair
Tumor Suppressors