TLK1 Products

Antibodies
TLK1 Antibody
TLK1 Antibody
NBP1-83035
Species: Hu, Mouse, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
TLK1 Antibody (4B3)
TLK1 Antibody (4B3)
H00009874-M01
Species: Hu
Applications: WB, ELISA, IHC, IHC-P
Host: Mouse Monoclonal
TLK1 Antibody
TLK1 Antibody
NBP1-32354
Species: Hu
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
Lysates
TLK1 Overexpression Lysate (N ...
TLK1 Overexpression Lysate (Native)
NBL1-16947
Applications: WB
Proteins
TLK1 Partial Recombinant Prot ...
TLK1 Partial Recombinant Protein
H00009874-Q01
Species: Hu
Applications: WB, ELISA, PA
TLK1 Recombinant Protein Anti ...
TLK1 Recombinant Protein Antigen
NBP1-83035PEP
Species: Hu
Applications: AC
RNAi
TLK1 RNAi
TLK1 RNAi
H00009874-R02
Species: Hu

Description

Tousled-like kinase 1 (TLK1) is a serine/threonine kinase involved in chromatin assembly and the DNA damage response. The tousled (Tsl) kinase was first identified in Arabidopsis thaliana and speculated to be involved in cell division during patterning of plant organs. There are two tousled-like kinases in humans, TLK1 and TLK2, that can dimerize or heterodimerize for function and can be phosphorylated and inactivated by Chk1 in response to DNA damage. The histone chaperone, Asf1 (anti-silencing function 1), has been reported as a substrate for both TLK1 and TLK2. TLK1 has also been shown to be important for cell cycle progression and proper chromosome segregation.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 9874
Alternate Names
  • PKU-BETA
  • EC 2.7.11
  • EC 2.7.11.1
  • SNARE protein kinase SNAK
  • PKU-beta
  • KIAA0137serine/threonine-protein kinase tousled-like 1
  • tousled-like kinase 1serine threonine protein kinase

Research Areas for TLK1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Cycle and Replication
Checkpoint signaling
Chromatin Research
DNA Repair
Tumor Suppressors

PTMs for TLK1

Learn more about PTMs related to TLK1.

Phosphorylation
Cleavage
Dephosphorylation

Bioinformatics Tool for TLK1

Discover related pathways, diseases and genes to TLK1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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