TIRAP (TLR2 and TLR4) Products

Description

Mammalian Toll-like receptors (TLRs) recognize conserved products of microbial metabolism and activate NF-kappa B and other signaling pathways through the adapter protein MyD88. All TLRs have a Toll/IL-1 receptor (TIR) domain, which is responsible for signal transduction. MyD88 is one such protein that contains a TIR domain. It acts as an adapter, being involved in TLR-2, TLR-4 and TLR-9 signaling. Toll-interleukin 1 receptor (TIR) domain-containing adapter protein (TIRAP) controls activation of MyD88-independent signaling pathways downstream of TLR4. Double-stranded RNA-binding protein kinase PKR is a component of both the TIRAP- and MyD88-dependent signaling pathways (1). It has been demonstrated that TRIF associates with TRAF6 and TBK1 independently, and activates two distinct transcription factors, NF- B and IFN regulatory factor-3, respectively (2). TIRAP is differentially involved in signaling by members of the TLR family and may account for specificity in the downstream signaling of individual TLRs (3).

Bioinformatics

Entrez	114609 Human 117149 Mouse 680127 Rat
Uniprot	AAH32474 Human AAH32474.1 Human AAL05627 (Human) Human AAL05627 Human NP_001034750 Human NP_001034750.1 Human NP_683708. Human P58753 Human Q56UH9 Human
Product By Gene ID	114609
Alternate Names	adapter protein wyatt Adaptor protein Wyatt FLJ42305 MAL Mal MyD88 adapter-like protein TIR domain-containing adapter protein toll/interleukin-1 receptor domain-containing adapter protein toll-interleukin 1 receptor (TIR) domain containing adaptor protein Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein Toll-like receptor adaptor protein wyatt

Research Areas for TIRAP (TLR2 and TLR4)

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