Tie-1 Products

Description

TIE1/TIE (tyrosine kinase with Ig and EGF homology domains 1) and TIE2/Tek define a new class of the receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin like domains flanking three epidermal growth factor (EFG) like domains followed by three fibronectin type III like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. Human TIE1 cDNA encodes a 1138 amino acid residue precursor protein with a putative signal peptide, an extracellular domain, and a cytoplasmic domain. Human TIE1/Fc, a disulfide linked homodimeric protein, has a calculated molecular mass of approximately 107 kDa. Due to glycosylation, the protein migrates to approximately 160 kDa in SDS PAGE under reducing conditions. TIE1 and TIE2, expressed primarily on endothelial and hematopoietic progenitor cells, play important roles in angiogenesis, vasculogenesis, and hematopoiesis. In developing vascular endothelial cells, TIE1 and TIE2 are specifically expressed. Two ligands that bind TIE have been identified, angiopoietin 1 and angiopoietin 2. Based on gene targeting studies, the in vivo functions of TIE1 are related to endothelial cell differentiation. The receptor tyrosine kinase TIE also plays a role in the survival and integrity of the endothelium.

Bioinformatics

Entrez	7075 Human
Uniprot	NM_005424 Human NP_005415 Human P35590 Human
Product By Gene ID	7075
Alternate Names	EC 2.7.10 EC 2.7.10.1 JTK14soluble TIE1 variant 3 receptor tyrosine kinase soluble TIE1 variant 1 soluble TIE1 variant 2 soluble TIE1 variant 5 TIEsoluble TIE1 variant 4 tyrosine kinase with immunoglobulin and epidermal growth factor homologydomains 1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 tyrosine-protein kinase receptor Tie-1

Research Areas for Tie-1

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Protein Kinase