Thymidine Kinase 2 Products

Antibodies
Thymidine Kinase 2 Antibody
Thymidine Kinase 2 Antibody
NBP1-92505
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Thymidine Kinase 2 Antibody
Thymidine Kinase 2 Antibody
NBP1-79890
Species: Hu
Applications: WB, IHC
Host: Rabbit Polyclonal
Thymidine Kinase 2 Antibody
Thymidine Kinase 2 Antibody
NBP2-33338
Species: Hu, Mu
Applications: WB, ELISA
Host: Rabbit Polyclonal
Proteins
Thymidine Kinase 2 Recombinan ...
Thymidine Kinase 2 Recombinant Pro...
NBP1-92505PEP
Species: Hu
Applications: AC
Recombinant Human Thymidine K ...
Recombinant Human Thymidine Kinase...
NBP1-98864
Species: Hu
Applications: PAGE
RNAi
Thymidine Kinase 2 RNAi
Thymidine Kinase 2 RNAi
H00007084-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

The mitochondrial deoxyribonucleotide (dNTP) pool is separated from the cytosolic pool because the mitochondria inner membrane is impermeable to charged molecules. The mitochondrial pool is maintained by either import of cytosolic dNTPs through dedicated transporters or by salvaging deoxynucleosides within the mitochondria; apparently, enzymes of the de novo dNTP synthesis pathway are not present in the mitochondria. In nonreplicating cells, where cytosolic dNTP synthesis is downregulated, mtDNA synthesis depends solely on the mitochondrial salvage pathway enzymes, the deoxyribonucleoside kinases. Two of the 4 human deoxyribonucleoside kinases, deoxyguanosine kinase (DGK) and thymidine kinase-2, are expressed in mitochondria. Human DGK, encoded by the DGUOK gene (MIM 601465), efficiently phosphorylates deoxyguanosine and deoxyadenosine, whereas TK2 phosphorylates deoxythymidine, deoxycytidine, and deoxyuridine. Thymidine kinase-2 (TK2) is a deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine, and also phosphorylates antiviral and anticancer nucleoside analogs.[supplied by OMIM]

Bioinformatics

Entrez Human
Uniprot Human
Human
Product By Gene ID 7084
Alternate Names
  • Mt-TK
  • EC 2.7.1.21
  • mt-TK
  • MTTK
  • MTDPS2
  • thymidine kinase 2, mitochondrial

PTMs for Thymidine Kinase 2

Learn more about PTMs related to Thymidine Kinase 2.

Phosphorylation
Glutathionylation
Reduction
Cleavage
Dephosphorylation

Bioinformatics Tool for Thymidine Kinase 2

Discover related pathways, diseases and genes to Thymidine Kinase 2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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