TGR5/GPBAR1 Products

Description

This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.

Bioinformatics

Product By Gene ID	151306
Alternate Names	BG37 BG37hBG37 G protein-coupled bile acid receptor 1 GPBA GPBAR1 GPCR19 GPR131 G-protein coupled bile acid receptor 1 G-protein coupled bile acid receptor BG37 G-protein coupled receptor GPCR19 M-BAR M-BARhGPCR19 membrane bile acid receptor Membrane-type receptor for bile acids MGC40597 TGR5 TGR5GPCR

Research Areas for TGR5/GPBAR1

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GPCR

Related TGR5/GPBAR1 Blog Posts

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The TGR5 Receptor and metabolic disease The bile acid-responsive G-protein-coupled receptor TGR5 is widely distributed across the human body - including the endocrine glands, adipocyte cells, muscles, immune organs, spinal cord, and the enteric nervous system. G protein coupled receptor...    Read more.

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