TGIF1 Products

Antibodies
TGIF1 Antibody (790707)
TGIF1 Antibody (790707)
MAB7555
Species: Hu
Applications: WB, Simple Western
Host: Mouse Monoclonal
TGIF1 Antibody (1B12)
TGIF1 Antibody (1B12)
NBP2-46109
Species: Hu
Applications: WB, IHC
Host: Mouse monoclonal
TGIF1 Antibody
TGIF1 Antibody
AF7555
Species: Hu
Applications: WB
Host: Sheep Polyclonal
Lysates
TGIF1 Overexpression Lysate ( ...
TGIF1 Overexpression Lysate (Native)
NBP2-05146
Applications: WB
TGIF1 Overexpression Lysate ( ...
TGIF1 Overexpression Lysate (Native)
NBP2-05145
Applications: WB
TGIF1 Overexpression Lysate ( ...
TGIF1 Overexpression Lysate (Native)
NBL1-16861
Applications: WB
Proteins
TGIF1 Recombinant Protein
TGIF1 Recombinant Protein
H00007050-P01
Species: Hu
Applications: WB, ELISA, PA
TGIF1 Partial Recombinant Pro ...
TGIF1 Partial Recombinant Protein
H00007050-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
TGIF1 RNAi
TGIF1 RNAi
H00007050-R06
Species: Hu
TGIF1 RNAi
TGIF1 RNAi
H00007050-R07
Species: Hu
TGIF1 RNAi
TGIF1 RNAi
H00007050-R04
Species: Hu

Description

Novel homeobox gene, denoted TGIF (interacting factor), belongs to an expanding TALE (three amino acid loop extension) superclass of atypical homeodomains. The TGIF homeodomain binds to a previously characterized retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE), which contains an unusual DNA target for a homeobox (1). In vitro studies have implicated TGIF as a transcriptional repressor and corepressor in retinoid and TGF-beta signaling pathways that regulate several important biological processes. Heterozygous nonsense and missense mutations of the human TGIF gene have been associated with holoprosencephaly, the most common congenital malformation of the forebrain (2). It has been reported that TGIF plays an unexpected role in the inhibition of Smad2 phosphorylation, which occurs by a mechanism independent of its association with Smad2. This inhibitory function of TGIF is executed in concert with c-Jun, which facilitates the interaction of TGIF with cPML, resulting in the nuclear sequestration of cPML and the disruption of the cPML-SARA complex (3).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 7050
Alternate Names
  • transforming growth factor-beta-induced factor
  • 5'-TG-3' interacting factor
  • TALE homeobox TG-interacting factor
  • TGFB-induced factor (TALE family homeobox)
  • homeobox protein TGIF1
  • HPE4
  • homeobox protein TGIF
  • TGIFMGC5066,5'-TG-3'-interacting factor 1
  • MGC39747
  • TGFB-induced factor homeobox 1

Research Areas for TGIF1

Find related products by research area and learn more about each of the different research areas below.

Core ESC-Like Genes
Stem Cell Markers

PTMs for TGIF1

Learn more about PTMs related to TGIF1.

Phosphorylation
Methylation
Ubiquitination

Bioinformatics Tool for TGIF1

Discover related pathways, diseases and genes to TGIF1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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