TGIF1 Products

Description

Novel homeobox gene, denoted TGIF (interacting factor), belongs to an expanding TALE (three amino acid loop extension) superclass of atypical homeodomains. The TGIF homeodomain binds to a previously characterized retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE), which contains an unusual DNA target for a homeobox (1). In vitro studies have implicated TGIF as a transcriptional repressor and corepressor in retinoid and TGF-beta signaling pathways that regulate several important biological processes. Heterozygous nonsense and missense mutations of the human TGIF gene have been associated with holoprosencephaly, the most common congenital malformation of the forebrain (2). It has been reported that TGIF plays an unexpected role in the inhibition of Smad2 phosphorylation, which occurs by a mechanism independent of its association with Smad2. This inhibitory function of TGIF is executed in concert with c-Jun, which facilitates the interaction of TGIF with cPML, resulting in the nuclear sequestration of cPML and the disruption of the cPML-SARA complex (3).

Bioinformatics

Entrez	21815 Mouse 316742 Rat 7050 Human
Uniprot	AAH00814 Human NM_170695 Human NM_173208 Human NM_173210 Human NM_174886 Human NP_003235 Human NP_775301 Human NP_775303 Human Q15583 Human
Product By Gene ID	7050
Alternate Names	5'-TG-3' interacting factor homeobox protein TGIF homeobox protein TGIF1 HPE4 MGC39747 TALE homeobox TG-interacting factor TGFB-induced factor (TALE family homeobox) TGFB-induced factor homeobox 1 TGIFMGC5066,5'-TG-3'-interacting factor 1 transforming growth factor-beta-induced factor

Research Areas for TGIF1

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Core ESC-Like Genes
Stem Cell Markers