TCEB2 Products

Description

TCEB2 encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Bioinformatics

Entrez	67673 Mouse 6923 Human
Uniprot	AAH13306 Human NM_007108 Human NP_009039 Human NP_009039.1 Human NP_996896 Human Q15370 Human
Product By Gene ID	6923
Alternate Names	18-kD subunit ELOB EloB Elongin 18 kDa subunit elongin-B Elongin-B RNA polymerase II transcription factor SIII p18 subunit RNA polymerase II transcription factor SIII subunit B SIII p18 transcription elongation factor B (SIII), polypeptide 2 (18kD, elongin B) transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) transcription elongation factor B polypeptide 2