TATA binding protein TBP Products

Description

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein TBP and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. A distinctive feature of TBP is a long string of glutamines in the N-terminal. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. Mutations that expand the number of CAG repeats encoding this polyglutamine tract, and thus increase the length of the polyglutamine string, are associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease.TPB is also known to interact with HIV1 Tat protein.

Bioinformatics

Entrez	117526 Rat 21374 Mouse 6908 Human
Uniprot	NM_003194 Human NP_003185 Human NP_003185.1 Human P20226 Human
Product By Gene ID	6908
Alternate Names	GTF2D GTF2D1 HDL4 MGC126054 MGC126055 SCA17 TATA box binding protein TATA sequence-binding protein TATA-binding factor TATA-box binding protein N-terminal domain TATA-box factor TATA-box-binding protein TF2D TFIIDMGC117320 Transcription initiation factor TFIID TBP subunit

Research Areas for TATA binding protein TBP

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Transcription Factors and Regulators