Tankyrase binding protein 1 Products

Description

TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen in search of tankyrase 1-interacting proteins. Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor). Ribosylation of TRF1 has been shown to result in the inhibition of TRF1 binding and an induction of telomere elongation. TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain. This finding suggests that TAB182 may act as a scaffold to mediate higher order protein complex formation at telomeres. TAB182 has also been suggested to serve a role in the cytoplasm as it has been found to localize to the cytoplasmic cortical actin network.

Bioinformatics

Entrez	85456 Human
Uniprot	NP_203754 Human NP_203754.2 Human Q9C0C2 Human
Product By Gene ID	85456
Alternate Names	tankyrase 1-binding protein of 182 kDa KIAA1741TAB182FLJ45975,182 kDa tankyrase-1-binding protein tankyrase 1 binding protein 1, 182kDa

Diseases related to Tankyrase binding protein 1

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Hearing Problem
Malignant Neoplasms

Pathways for Tankyrase binding protein 1

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Regeneration
Localization

PTMs for Tankyrase binding protein 1

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Ribosylation

Bioinformatics Tool for Tankyrase binding protein 1

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