Hu, Mu, Rt, Ch, Fe, PmApplications:
WB, ELISA, ICC/IF, IHC, IHC-Fr, IHC-P, IPHost:
WB, ELISA, IHC, IHC-PHost:
Hu, Mu, Rt, Pm, Bv, SqApplications:
WB, ICC/IF, IHC, IHC-Fr, IHC-PHost:
WB, ELISA, Func, PA, AP, B/N
Synaptophysin (Syp I), also called the major synaptic vesicle protein p38, is an integral membrane glycoprotein found in the synaptic vesicles of brain, neuron and neuroendocrine cells. Synaptophysin is one of the most abundant membrane proteins, comprising approximately 7% of the total protein in small synaptic vesicles. In mature nerve terminals it forms a complex with the vesicular membrane protein synaptobrevin, which appears to modulate synaptobrevin's interaction with the plasma membrane-associated proteins syntaxin and SNAP25 to form the SNARE complex as a prerequisite for membrane fusion. Synaptophysin may also be used as a neuroendocrine tumor marker in both neuroscience and cancer research.