Src Products

Antibodies
Src Antibody (1246F) [Unconju ...
Src Antibody (1246F) [Unconjugated]
MAB2685
Species: Hu
Applications: WB, Simple Western, ICC
Host: Rabbit Monoclonal
Src [p Tyr418] Antibody
Src [p Tyr418] Antibody
NB100-92633
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Src [p Tyr419] Antibody [Unco ...
Src [p Tyr419] Antibody [Unconjuga...
Species: Hu
Applications: WB, Simple Western, IHC
Host: Rabbit Polyclonal
Lysates
Src Overexpression Lysate (De ...
Src Overexpression Lysate (Denatured)
H00006714-T01
Species: Hu
Applications: WB
Src Overexpression Lysate (Na ...
Src Overexpression Lysate (Native)
NBP2-04722
Applications: WB
Src Overexpression Lysate (Na ...
Src Overexpression Lysate (Native)
NBP2-07751
Applications: WB
Proteins
Src Recombinant Protein
Src Recombinant Protein
H00006714-P01
Species: Hu
Applications: WB, ELISA, PA
Src Recombinant Protein Antig ...
Src Recombinant Protein Antigen
NBP2-38165PEP
Species: Hu
Applications: AC
Src Recombinant Protein
Src Recombinant Protein
NBP1-99484
RNAi
Src RNAi
Src RNAi
H00006714-R03
Species: Hu
Applications: RNAi, RNAi SP
Src RNAi
Src RNAi
H00006714-R04
Species: Hu
Applications: RNAi, RNAi SP

Description

Src is a protein tyrosine kinase known to regulate cellular adhesion. Composed of three major domains; SH2, SH3 and a kinase catalytic domain, Src can be switched from an inactive to an active state though control of its phosphorylation state or through protein-protein interaction. Phosphorylation of Y529 by Csk and Chk inactivates Src, while dephosphorylation of Y529 will modify its conformation to an open active state (1-3). Mutation of Y529 leads to Scr overactivity. Several cancers including colon and breast cancer have been associated with an increase of Src activity (4).

Bioinformatics

Entrez Human
Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 6714
Alternate Names
  • EC 2.7.10
  • pp60c-src
  • v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
  • tyrosine-protein kinase SRC-1
  • c-src
  • tyrosine kinase pp60c-src
  • EC 2.7.10.2
  • Rous sarcoma
  • v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)

Research Areas for Src

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Protein Kinase
Signal Transduction
Transcription Factors and Regulators
Tyrosine Kinases

Bioinformatics Tool for Src

Discover related pathways, diseases and genes to Src. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related Src Blog Posts

Check out the latest blog posts on Src.
Androgen Receptor: What Makes a Man?
Steroid receptors (SRs) are a superfamily of ligand-dependent nuclear transcription factors that activate responsive genes response to hormone. Androgen receptors (ARs) are found in a wide variety of tissues, including reproductive organs, central ner...    Read more.
The Heat is On: Heat Shock Proteins and the Link to Cancer
Novus Biologicals offers an extensive antibody catalog targeting heat shock proteins (HSPs). A large protein group covering a number of families, the HSPs are functionally related by their dramatic upregulation in response to stress. Stress triggers m...    Read more.
Read more Src related blogs.