SPEN Products

Description

SPEN encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors.

Bioinformatics

Entrez	23013 Human
Uniprot	NP_055816.2 Human Q96T58 Human
Product By Gene ID	23013
Alternate Names	HIAA0929 KIAA0929nuclear receptor transcription cofactor MINTMsx2 interacting nuclear target (MINT) homolog RBM15C SHARPmsx2-interacting protein SMART/HDAC1 associated repressor protein SMART/HDAC1-associated repressor protein SPEN homolog spen homolog, transcriptional regulator (Drosophila)