SPAM1 Products

SPAM1 Antibody
SPAM1 Antibody
Species: Hu
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
SPAM1 Antibody
SPAM1 Antibody
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
SPAM1 Antibody
SPAM1 Antibody
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
SPAM1 Overexpression Lysate
SPAM1 Overexpression Lysate
Species: Hu
Applications: WB
Recombinant Bovine SPAM1 Prot ...
Recombinant Bovine SPAM1 Protein, CF
Species: Bv
Applications: Enzyme Activity
Formulation Catalog # Availability Price  
SPAM1 Recombinant Protein Ant ...
SPAM1 Recombinant Protein Antigen
Species: Hu
Applications: AC


Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq]


Entrez Human
Uniprot Human
Product By Gene ID 6677
Alternate Names
  • Sperm adhesion molecule 1
  • HYA1
  • Hyal-PH20
  • PH20
  • EC
  • HYAL3
  • hyaluronidase PH-20
  • Sperm surface protein PH-20
  • hyal-PH20
  • Hyaluronoglucosaminidase PH-20
  • SPAG15
  • PH-20
  • MGC26532
  • HYAL5
  • HYAL1
  • sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)

PTMs for SPAM1

Learn more about PTMs related to SPAM1.

Gpi Anchoring

Bioinformatics Tool for SPAM1

Discover related pathways, diseases and genes to SPAM1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Vizit™, under license from BioVista Inc.

Related SPAM1 Blog Posts

Check out the latest blog posts on SPAM1.
Funny Protein Names Infographic
This is not a joke, these proteins with funny names actually do exist. View our list of six proteins with funny and unusual names including: Bambi, Yippee-like 3, Wee1, SPAM1, SPOCK1 and Bagpipe homeobox protein homolog 1. Learn more about their fu...    Read more.
Read more SPAM1 related blogs.