SORBS2 Products

Description

Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]

Bioinformatics

Entrez	8470 Human
Uniprot	NP_003594 Human NP_066547 Human NP_066547.1 Human
Product By Gene ID	8470
Alternate Names	Arg/Abl interacting protein Arg/Abl-interacting protein 2 ArgBP2 ARGBP2PRO0618 FLJ93447 KIAA0777Arg binding protein 2 sorbin and SH3 domain containing 2 sorbin and SH3 domain-containing protein 2 Sorbin

Research Areas for SORBS2

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Lipid and Metabolism