Species: Hu
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, Flow, ICC/IF
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: PAGE, Enzyme Activity
Species: Hu
Applications: PAGE, Enzyme Activity
Species: Hu
Applications: Binding Activity
Description
Sorbitol dehydrogenase (SDH), a member of the medium-chain dehydrogenase/reductase protein family and the second enzyme of the polyol pathway of glucose metabolism, converts sorbitol to fructose strictly using NAD(+) as coenzyme. SDH is expressed almost ubiquitously in all mammalian tissues. The enzyme has attracted considerable interest due to its implication in the development of diabetic complications as the polyol pathway is particularly active in hyperglycemic states. Although SORD is closely related to the class I long-chain alcohol dehydrogenases, it differs in substrate specificity, catalyzing polyols such as sorbitol and xylitol but having no activity towards primary alcohols.
Bioinformatics
Entrez |
Mouse Human Human |
Uniprot |
Human Human Human Human |
Product By Gene ID |
6652 |
Alternate Names |
- EC 1.1.1
- EC 1.1.1.14
- L-iditol 2-dehydrogenase
- sorbitol dehydrogenase
- SORD1
|
PTMs for Sorbitol Dehydrogenase
Learn more about PTMs related to Sorbitol Dehydrogenase.
Phosphorylation
Bioinformatics Tool for Sorbitol Dehydrogenase
Discover related pathways, diseases and genes to Sorbitol Dehydrogenase. Need help? Read the
Bioinformatics Tool Guide for instructions on using this tool.