Sorbitol Dehydrogenase Products

Description

Sorbitol dehydrogenase (SDH), a member of the medium-chain dehydrogenase/reductase protein family and the second enzyme of the polyol pathway of glucose metabolism, converts sorbitol to fructose strictly using NAD(+) as coenzyme. SDH is expressed almost ubiquitously in all mammalian tissues. The enzyme has attracted considerable interest due to its implication in the development of diabetic complications as the polyol pathway is particularly active in hyperglycemic states. Although SORD is closely related to the class I long-chain alcohol dehydrogenases, it differs in substrate specificity, catalyzing polyols such as sorbitol and xylitol but having no activity towards primary alcohols.

Bioinformatics

Entrez	20322 Mouse 6652 Human 823 Human
Uniprot	AAH21085 Human NM_003104 Human NP_003095 Human Q00796 Human
Product By Gene ID	6652
Alternate Names	EC 1.1.1 EC 1.1.1.14 L-iditol 2-dehydrogenase sorbitol dehydrogenase SORD1

Diseases related to Sorbitol Dehydrogenase

Discover more about diseases related to Sorbitol Dehydrogenase.

Complications Of Diabetes Mellitus
Diabetes Mellitus
Malignant Neoplasms
Neoplasms
Malignant Paraganglionic Neoplasm
Bilateral Cataracts (disorder)
Sclerosis
Neoplasm Metastasis
Nystagmus
Malignant Neoplasm Of Lung
Nervousness
Dog Diseases
Malignant Neoplasm Of Prostate
Adenocarcinoma
Ocular Adnexal Lymphoma
Lung Neoplasms
Pleural Effusion Disorder
Pleural Effusion, Malignant

Pathways for Sorbitol Dehydrogenase

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Sperm Capacitation
Pathogenesis
Flight
Mrna Splicing
Sperm Motility
Cognition
Spermatogenesis
Secretion

Research Areas for Sorbitol Dehydrogenase

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Diabetes Research
Lipid and Metabolism

PTMs for Sorbitol Dehydrogenase

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Phosphorylation

Bioinformatics Tool for Sorbitol Dehydrogenase

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