SMURF2 Products

Antibodies
SMURF2 Antibody (690638)
SMURF2 Antibody (690638)
MAB6916
Species: Hu, Mu, Rt
Applications: WB
Host: Mouse Monoclonal
SMURF2 Antibody
SMURF2 Antibody
NBP1-31211
Species: Hu, Mouse, Rat, Xenopus, Zebrafish
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
SMURF2 Antibody
SMURF2 Antibody
NBP2-20427
Species: Hu
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
SMURF2 Overexpression Lysate ...
SMURF2 Overexpression Lysate (Native)
NBL1-16260
Applications: WB

Description

Smad ubiquitination regulatory factor proteins (Smurf1 and Smurf2) are E3 ubiquitin ligase that belongs to the Hect family. Smurf proteins play an important role as regulators in TGF-beta pathway by ubiquitinating Smads and Smads associated proteins for proteasome degradation (1). Specifically, Smurf1 interacts with Smad1 and Smad5 for degradation, while Smurf2 ubiquitinates Smad1 and Smad2. Smads also functions to recruit Smurfs to various pathway components such as TGF-beta and SnoN. In particular, Smad7 acts as an adaptor protein between Smurfs and TGF-Beta receptors, allowing the receptors to be marked by Smurfs for degradation (2). Smurf2 interacts with all members of Smad family except for Smad4 and it is expressed various tissues and cell lines, such as placenta and ovarian cancer cell lines. Smurf2 has been implicated in the tumor formation and diseases progression (3).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Product By Gene ID 64750
Alternate Names
  • EC 6.3.2
  • DKFZp686F0270
  • EC 6.3.2.-
  • SMAD-specific E3 ubiquitin-protein ligase 2
  • E3 ubiquitin-protein ligase SMURF2
  • SMAD ubiquitination regulatory factor 2
  • E3 ubiquitin ligase SMURF2
  • hSMURF2
  • MGC138150
  • SMAD specific E3 ubiquitin protein ligase 2

PTMs for SMURF2

Learn more about PTMs related to SMURF2.

Ubiquitination
Phosphorylation
Acetylation
Deacetylation
Dephosphorylation
Methylation

Bioinformatics Tool for SMURF2

Discover related pathways, diseases and genes to SMURF2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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