SMC1 Products

Description

Involved in chromosome cohesion during cell cycle and in DNA repair and is a central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. SMC1 is involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, and works as a downstream effector in the ATM/NBS1 branch of S-phase checkpoint.

Bioinformatics

Entrez	8243 Human
Uniprot	Q14683
Product By Gene ID	8243
Alternate Names	CDLS2 DXS423ESMC1 structural maintenance of chromosomes 1-like 1 (yeast) KIAA0178DKFZp686L19178 SB1.8 SB1.8MGC138332 segregation of mitotic chromosomes 1 SMC protein 1A SMC1 (structural maintenance of chromosomes 1, yeast)-like 1 SMC1 structural maintenance of chromosomes 1-like 1 SMC1 SMC1A SMC-1A SMC-1-alpha SMC1L1 SMC1SMC1alpha Smcb structural maintenance of chromosomes 1A structural maintenance of chromosomes protein 1A

Research Areas for SMC1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Cycle and Replication
Checkpoint signaling
Chromatin Research
DNA Double Strand Break Repair
DNA Repair
Phospho-Specific