SMARCAD1 Products

Description

The SMARCs (SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin), and BAFs (BRG1-associated factors), have been identified as components of the mammalian SWI/SNF-like chromatin remodeling protein complexes. These multi-protein complexes are proposed to function as ATP-driven motors that translocate along DNA and destabilize nucleosomal structures to facilitate transcription factor binding. SMARCAD1/ETL1 is a unique member of this family in that it contains two DEAD/H box motifs, and thus is also a member of the DEAD/H-box-containing helicase superfamily. The chromosomal position of SMARCAD1 has been mapped, and it resides in a region rich in breakpoints and deletions associated with several human diseases. It is suggested to play a role in genetic instability and development.

Bioinformatics

Entrez	56916 Human
Uniprot	AAH45534.1 Human NM_020159 Human Q9H4L7 Human
Product By Gene ID	56916
Alternate Names	ATP-dependent helicase 1 DKFZP762K2015 EC 3.6.1 EC 3.6.4.12 HEL1 hHEL1 KIAA1122ETL1DKFZp762K2015 subfamily a, containing DEAD/H box 1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatinsubfamily A containing DEAD/H box 1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin

Research Areas for SMARCAD1

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DNA Repair