Slit2 Products

Description

Slit proteins are ligands at the Roundabout (Robo) receptors and act as guidance cues in axonal migration/navigation during neural development, at the ventral midline of the neural tube. Slit1 and Slit2 are essential for midline guidance in the forebrain by acting as repulsive signals preventing inappropriate midline crossing by axons projecting from the olfactory bulb. A number of cleavage products are reported in the literature for Slit2 protiens (following alternate splicing). The C-terminal cleavage proteins are more diffusible than the larger N-terminal protein that is more tightly cell associated. Slit2 protein is expressed in fetal lung and kidney, and adult spinal cord. Weak expression in adult adrenal gland, thyroid, trachea.

Bioinformatics

Entrez	20563 Mouse 360272 Rat 9353 Human
Uniprot	NM_004787 Human NP_004778 Human NP_004778.1 Human O94813 Human
Product By Gene ID	9353
Alternate Names	FLJ14420 slit (Drosophila) homolog 2 slit homolog 2 (Drosophila) slit homolog 2 protein Slit-2SLIL3

Research Areas for Slit2

Find related products by research area and learn more about each of the different research areas below.

Growth and Development
Neuronal Cell Markers
Neuroscience
Signal Transduction